Osteoarthritis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between 30 and 80 years old (inclusive)
• People whose knee X-ray shows a level of arthritis graded 2 to 4 on a standard scale called the Kellgren-Lawrence scale
• People who have a specific type of bone injury called a bone marrow lesion (BML), visible on an MRI scan, in a weight-bearing area of the knee (the inner or outer parts of the thigh bone or shin bone where they meet the knee)
• People who have had knee pain for more than 2 months
• People whose knee pain, in the week before the screening visit, rated at least 4 out of 10 on a pain scale (where 0 means no pain and 10 means the worst pain imaginable)
• People whose knee pain is located in the same part of the knee where the bone marrow lesion is found
• People who have already tried at least 4 weeks of basic treatments without enough relief, such as rest, pain relief medication, or reducing weight on the knee (with or without a walking aid)

Who may not be able to join:

• People whose bone marrow lesion was caused by a physical injury or trauma
• People whose main cause of knee pain and loss of function comes from a condition other than a bone marrow lesion, based on their medical history and a clinical assessment
• People who have bone marrow lesions in both knees
• People with systemic autoimmune diseases, such as lupus or rheumatoid arthritis
• People currently taking steroid medications (glucocorticoids) for any other health condition
• People who have previously had certain treatments for bone marrow lesions, including a procedure called subchondroplasty in the affected knee, or injections of biological substances (such as platelet-rich plasma, bone marrow concentrate, or fat-derived treatments) into the knee joint or bone within the past 6 months
• People who have previously taken bone-strengthening medications called bisphosphonates, unless enough time has passed since stopping them — the required gap depends on how long the medication was taken and how it was given (confirm with trial site for specific timeframes)
• People who have had a steroid injection into the knee joint within the past 3 months
• People who have had knee surgery within the past 6 months
• People with tumours
• People with an active infection or fracture in the same leg as the affected knee
• People who are pregnant
• People who have medical reasons they cannot receive a treatment called focused extracorporeal shockwave therapy (f-ESWT), such as serious blood clotting disorders or a malignant tumour in the treatment area
• People who are unable to have an MRI scan, including those with certain metal implants in their body (such as a pacemaker, metal heart valve, cochlear implant, brain stimulator, or metal fragments near the eyes), those with claustrophobia, or those whose doctor has advised that MRI scanning is not medically safe for them

Important: Always verify eligibility with the trial site directly before applying.