Alzheimer's Disease Trial, By Invitation

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For people with normal memory and thinking (Cognitively Normal group):

• People who may or may not have concerns about their memory, whether noticed by themselves, a family member, or a doctor
• People whose memory test scores fall within the normal range for their level of education, based on a standard memory test
• People who score between 24 and 30 on a standard thinking and memory assessment called the Mini-Mental State Exam (exceptions may be considered for those with fewer than 8 years of education — confirm with trial site)
• People whose overall thinking and daily functioning is rated as fully normal by a clinician

For people with mild memory concerns (Mild Cognitive Impairment group):

• People who have a noticeable concern about their memory, reported by themselves, a family member, or a doctor
• People whose memory test scores fall below the normal range for their level of education, based on a standard memory test
• People who score between 24 and 30 on the Mini-Mental State Exam (exceptions may be considered for those with fewer than 8 years of education — confirm with trial site)
• People whose overall thinking and daily functioning is rated as mildly affected, but not severe enough for a dementia diagnosis

For people with dementia (Dementia group):

• People who have a noticeable concern about their memory, reported by themselves, a family member, or a doctor
• People whose memory test scores fall below the normal range for their level of education, based on a standard memory test
• People who score between 20 and 28 on the Mini-Mental State Exam (exceptions may be considered for those with fewer than 8 years of education — confirm with trial site)
• People who have received a diagnosis of dementia according to recognised medical guidelines for Alzheimer's disease

For all groups (applying to everyone):

• People aged between 55 and 90 years
• People who score below 10 on a standard depression screening questionnaire
• People who have a study partner (such as a family member or friend) who spends at least 2 hours per week with them and can either attend clinic visits or provide information by phone
• People with adequate vision and hearing to complete thinking and memory tests
• People who are generally in good health, with no conditions expected to interfere with the study
• Women who are at least two years past menopause or have had a surgical procedure that means pregnancy is not possible
• People who are willing and able to take part in a long-term study that includes brain scans
• People who can read and speak English or Spanish fluently
• People who agree to have blood collected for genetic testing, including tests related to Alzheimer's risk
• People who agree to have blood collected for biological marker testing
• People who agree to take part in thinking and memory assessments, MRI scans, and PET scans
• People who have been taking any permitted medications at a stable dose for at least 4 weeks before the start of the study (certain medications are specifically listed as acceptable — confirm with trial site)
• Some criteria may have flexibility for people who have lived in a low-income area for at least 8 years (confirm with trial site)

For people who previously took part in an earlier ADNI study (Rollover participants):

• People who were enrolled and followed in a previous ADNI study (ADNI-GO, ADNI2, or ADNI3) for at least one year
• People who are willing and able to continue taking part in an ongoing long-term study

Who may not be able to join:

For people in the Cognitively Normal group:

• People who have a significant neurological condition such as Parkinson's disease, Huntington's disease, brain tumour, multiple sclerosis, epilepsy, a history of significant head injury with lasting effects, or other known structural brain abnormalities

For people in the Mild Cognitive Impairment or Dementia groups:

• People who have a significant neurological condition other than suspected Alzheimer's disease, such as Parkinson's disease (though some Parkinson's-related movement symptoms alongside memory problems may be acceptable — confirm with trial site), Huntington's disease, brain tumour, multiple sclerosis, epilepsy, a history of significant head injury with lasting effects, or other known structural brain abnormalities

For all groups (applying to everyone):

• People whose brain MRI scan shows signs of infection or other significant abnormalities in specific areas of the brain
• People whose brain MRI scan shows large structural changes that would interfere with the way brain images are analysed
• People who are unable to have an MRI scan for any reason, such as having a pacemaker or other metal implant in the body, or severe claustrophobia or anxiety that prevents scanning
• People who have had a diagnosis of major depression or bipolar disorder within the past year, or who have had significant behavioural or psychological symptoms within the past 3 months that could make it difficult to follow the study plan
• People currently taking medication for obsessive-compulsive disorder or attention deficit disorder
• People with a history of schizophrenia
• People with a history of alcohol or substance misuse disorder within the past 2 years
• People with a significant ongoing illness or unstable health condition that could make it difficult to follow the study plan
• People with clinically significant abnormalities in vitamin B12 or thyroid function that may affect the study (low B12 may be exclusionary unless follow-up blood tests show it is not causing a physical problem — confirm with trial site)
• People currently living in a skilled nursing facility
• People currently taking certain mental health or sedative medications, as determined by the treating clinician
• People currently taking other medications that are specifically excluded from this trial (confirm with trial site)
• People who have taken an experimental medication within five half-lives of that medication or one month before joining — whichever is the longer period — or who plan to take one during the trial
• People who are already taking part in another study that involves the same type of thinking and memory tests more than once per year
• Women who are pregnant or breastfeeding, or who could become pregnant
• Some criteria may have flexibility for people who have lived in a low-income area for at least 8 years (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.