Peripheral Arterial Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 50 years or older.
• People who have been diagnosed with peripheral artery disease (PAD), a condition where blood flow to the legs is reduced, confirmed through specific circulation tests or imaging showing significant artery narrowing.
• People whose circulation test results fall within a borderline range and show a notable drop in blood flow after a heel-rise exercise test.

Who may not be able to join:

• People who have had an amputation of part or all of either leg.
• People with severely reduced blood flow to the legs causing pain even at rest (a serious stage of PAD called critical limb ischemia).
• People who use a wheelchair full-time or need a walker to get around.
• People whose walking ability is limited by a condition other than PAD.
• People who currently have an open sore or ulcer on the bottom of a foot.
• People who do not complete the required study preparation period (the "run-in" phase).
• People who have major surgery, heart procedures, or leg artery procedures planned within the next five months.
• People who have had major surgery, heart procedures, leg artery procedures, or a serious heart event in the past three months.
• People with serious medical conditions such as lung disease requiring oxygen use during the day, Parkinson's disease, a life-threatening illness with a life expectancy of less than six months, or cancer that has required treatment in the past two years. (People treated for an early-stage cancer with an excellent outlook, or those who only need oxygen at night, may still be considered — confirm with trial site.)
• People who score below a certain threshold on a standard memory and thinking assessment (confirm with trial site).
• People with an allergy to beetroot juice.
• People who are currently consuming beetroot juice, beet supplements, or oral nitrate or nitrite products and who are not willing to stop taking them for 30 days before the study begins and throughout the trial.
• People who currently eat one cup or more of beets daily and are not willing to reduce this for 30 days before the study begins and throughout the trial.
• People who do not speak English.
• People who have taken part in or completed another clinical trial in the past three months. (Different timeframes may apply depending on the type of trial previously completed — confirm with trial site.)
• People whose vision problems affect their ability to walk.
• People whose walking distance in a six-minute walking test falls below 500 feet or above 1,600 feet. (The trial team may use their judgement for those who walk more than 1,600 feet — confirm with trial site.)
• People whose resting blood pressure is below 100/45.
• People who have taken part in a supervised treadmill exercise program in the past three months.
• People who currently use an antibacterial mouthwash (such as one containing chlorhexidine) and are not willing to stop using it.
• People with significantly reduced kidney function or elevated potassium levels in their blood (confirm specific values with trial site).
• People with a history of kidney stones that requires them to limit foods containing oxalate (a substance found in beetroot).
• People whom the trial investigators determine, based on their clinical judgement, are not suitable or safe candidates for the trial.

Important: Always verify eligibility with the trial site directly before applying.