Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with certain types of large B-cell lymphoma (confirmed by tissue testing), including specific subtypes defined by a standard medical classification system, whose cancer has come back or stopped responding to at least 2 previous rounds of treatment
• People aged 18 or older
• People whose general physical wellbeing falls within a certain range on a standard health scale (meaning they are able to carry out daily activities, with at most limited restrictions)
• People whose lymphoma has spread to the brain or spinal cord may still be eligible, provided they have no symptoms from that spread that would make it difficult for doctors to properly monitor for a specific type of side effect affecting the nervous system
• People whose life expectancy (from causes other than the lymphoma itself) is estimated to be more than 3 months
• People who are able to have children and are willing to use birth control from the time of joining the trial and for four months after receiving the pre-treatment regimen
• People who have read, understood, and signed a consent form before any trial-related procedures begin
• People who are able to give informed consent on their own behalf

Who may not be able to join:

• People whose blood test results show that certain white blood cell counts, platelet counts, or lymphocyte (immune cell) counts are below specific thresholds
• People whose lymphoma started in the brain or spinal cord (primary CNS lymphoma)
• People with a known history of hepatitis B or C infection, unless they have been treated and confirmed by a specific type of blood test to have no detectable virus
• People with an active HIV infection where the virus is still detectable in the blood, or where a specific immune cell count has fallen below a certain level
• People with a known history of seizures, or who have been taking anti-seizure medication at any point in the past 12 months
• People who have had a stroke in the past 12 months
• People with unstable neurological problems (issues affecting the brain or nervous system that are not stable)
• People with a known history or current diagnosis of an autoimmune disease affecting the brain or nervous system, such as multiple sclerosis or optic neuritis
• People with an active autoimmune disease that currently requires medication to suppress the immune system
• People with a brain or nervous system condition that, in the treating doctor's judgement, would make it difficult to properly monitor for neurological side effects, or a level of memory or thinking impairment that would interfere with treatment or monitoring (assessed using a standard test at the start of the trial)
• People with an active fungal, viral, or bacterial infection
• People with significant heart failure or a heart pumping function below a certain level on testing
• People whose blood oxygen level at rest, while breathing normal air, falls below 92%
• People with significant liver problems, as shown by certain blood test results being more than 5 times above the normal range — unless the liver results are directly caused by the lymphoma or by a specific inherited condition called Gilbert's disease
• People whose kidneys are not filtering blood efficiently enough, based on a standard calculation
• People who are pregnant or breastfeeding
• People who are currently being treated for another active cancer
• People who require long-term use of medications that suppress the immune system, with the exception of a low dose of a specific steroid (prednisolone at less than 10 mg per day)
• People who have had a severe allergic reaction to any drug or its ingredients that is planned to be used during the trial (confirm with trial site)
• People whose personal, family, social, or geographic circumstances may make it difficult to follow the trial schedule and requirements

Important: Always verify eligibility with the trial site directly before applying.