Oesophageal Cancer Trial, Recruiting NCT05642338 Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Condition: Oesophageal Cancer
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Oesophageal Cancer Trial, Recruiting

NCT05642338
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • Adults aged 18 years or older
  • People with Barrett's oesophagus (a condition affecting the lining of the food pipe) where the affected area meets specific size requirements — either spreading around at least 2 cm of the food pipe with a total length of no more than 18 cm, or a smaller circular spread with a total length of at least 4 cm (confirm exact measurements with trial site)
  • Cohort 1: People who have been referred for assessment of abnormal or precancerous cell changes in the food pipe — ranging from uncertain cell changes through to early-stage, low-risk cancer — detected either through routine biopsies or through a previous tissue removal procedure within the last 18 months
  • Cohort 2: People who have a known Barrett's oesophagus diagnosis but no detected cell changes in the last 18 months, and who are already attending regular monitoring check-ups
  • People who are able to give written consent and understand what taking part in the trial involves

Who may not be able to join:

  • People who have visible growths or raised areas in the food pipe (as classified by a standard medical grading system) at the time of the trial's testing procedures
  • People who have had a tissue removal procedure that revealed a higher-risk cancer — for example, one that has spread more deeply, is poorly formed, has spread into blood or lymph vessels, or was not fully removed
  • People who have had an endoscopy procedure with tissue sampling or removal within the past six weeks
  • People who have had surgery on the oesophagus (food pipe) or stomach, other than a specific anti-reflux operation called Nissen fundoplication
  • People who have previously had ablation therapy (a treatment that destroys tissue) on the food pipe
  • People who have varicose veins in the oesophagus (swollen veins in the food pipe)
  • People with an ongoing, unresolved alcohol or drug dependency that may affect their ability to understand consent or follow trial instructions

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: prof Bergman, MD, PhD, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Phone: +31617741850

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Registry
ClinicalTrials.gov
Start date
1 November 2022
Est. completion
1 May 2027

Where this trial is recruiting

🇳🇱 Netherlands

Primary endpoints

HGD/EAC

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov