Phase 3 Ankylosing Spondylitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old and have been diagnosed with axial spondyloarthritis (a type of inflammatory spine condition), with or without changes visible on an X-ray.
• Your condition is still active — meaning your symptoms score 4 or higher (out of 10) on a standard symptom scale, and your back pain also scores 4 or higher, even after at least 6 months of treatment with at least 2 different anti-inflammatory medicines and at least one biological therapy (a type of advanced medication).
• You may continue taking certain medicines (such as anti-inflammatories, some disease-modifying drugs, or low-dose steroids) as long as the doses have not changed in the 4 weeks before the study starts.
• You may continue taking certain advanced biological or targeted therapies as long as the doses have not changed in the 3 months before the study starts.
• If you are a woman who could become pregnant, you must be using effective contraception during at least the main treatment phase of the trial.
• You have health insurance coverage (certain types may be excluded — confirm with trial site).
• You are willing to sign a consent form and follow the study plan.

Who may not be able to join:

• You are under a legal guardianship or protection order.
• The study doctor believes you may have difficulty following the study rules, or there is a language or cognitive barrier that would prevent participation.
• You are currently pregnant or breastfeeding.
• You have inflammatory bowel disease (such as Crohn's disease or ulcerative colitis) that is currently active.
• You have had a steroid injection in the 4 weeks before joining the study.
• You currently have an active infection.
• You have taken antibiotics (including sulfasalazine) or antifungal medicines in the 4 weeks before joining.
• You have taken probiotic supplements in the 4 weeks before joining.
• You have had a known infection with certain bacteria (C. difficile or E. coli) in the 10 days before joining.
• You have another serious or unstable health condition that could interfere with the study, according to the doctor's judgment.
• You have previously received a fecal microbiota transplant (a treatment involving donor gut bacteria).
• You have a medical reason why you cannot take the bowel preparation medicine used in this study (confirm with trial site).
• You have a current or past history of bowel blockage.
• You have confirmed or suspected reduced blood supply to the intestines.
• You have confirmed or suspected severe bowel complications such as toxic megacolon or a hole in the bowel.
• More than two-thirds of your colon has been surgically removed.
• You have had any gastrointestinal bleeding in the 3 months before joining.
• You have had any bowel surgery in the 3 months before joining.
• You have severe dysfunction of a major organ (such as the liver or kidneys) (confirm with trial site).
• You are unable to swallow capsules.
• You have a known allergy or intolerance to the study treatment or its ingredients.
• You do not have access to a refrigerator to store the study medication at home.
• You are currently taking part in another clinical trial involving a treatment or intervention.

Important: Always verify eligibility with the trial site directly before applying.