Phase 2 Macular Degeneration Trial, Recruiting NCT05672121 Sponsor: Chengdu Origen Biotechnology Co., Ltd. Condition: Macular Degeneration
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Phase 2 Macular Degeneration Trial, Recruiting

NCT05672121
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are willing and able to sign a consent form agreeing to take part in the study
  • You are a man or woman between 50 and 85 years old and have been diagnosed with wet age-related macular degeneration (wet AMD)
  • You are currently receiving anti-VEGF injections for wet AMD and have had at least 3 injections in the 6 months before the screening visit
  • Your eye has shown a positive response to the anti-VEGF injections, meaning there has been a measurable reduction in fluid or swelling in the back of your eye
  • Your vision in the study eye falls within a specific range — not too strong and not too weak (confirm with trial site for exact details)
  • The study eye has already had a lens implant (cataract surgery) at least 3 months before joining the trial
  • If you are female, you must have gone through menopause at least 1 year ago

Who may not be able to join:

  • Your macular or central vision problems are caused by something other than wet AMD, such as severe short-sightedness or another eye disease
  • There is something in or around your study eye (such as cloudiness or an implant) that would make it difficult to examine the back of the eye, or your pupil is too small to allow proper examination
  • You have had, or currently have, a detached retina in the study eye
  • You have glaucoma or high pressure in the eye that is not well controlled
  • You have taken any medication known to be harmful to the retina
  • You have had any surgery inside the study eye
  • You have high blood pressure that is not well controlled, even with medication, at the time of your screening visit

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 21 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Wenbin Wei, PhD, Beijing Tongren Hospital Affiliated to Capital Medical University

Phone: 86 13880331037

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Chengdu Origen Biotechnology Co., Ltd.
Registry
ClinicalTrials.gov
Start date
6 February 2023
Est. completion
28 December 2026

Where this trial is recruiting

🇨🇳 China

Primary endpoints

Safety; Change in best corrected visual acuity

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov