Phase 3 Glaucoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older who have signed a consent form agreeing to take part in the trial.
• People diagnosed with open-angle glaucoma, pseudoexfoliation glaucoma, or pigmentary glaucoma.
• People whose vision in the study eye, when corrected with glasses or contact lenses, meets a minimum level of sharpness (confirm with trial site for exact threshold).
• People whose eye pressure in the study eye is well controlled, averaging 18 mmHg or below across the last three clinic measurements.
• People whose visual field (side and peripheral vision) test results show a loss no worse than -12 dB at their most recent assessment.
• People whose visual field loss is progressing slowly, at a rate of between -0.5 and -1.0 dB per year, based on at least 4 visual field tests taken during a period when no glaucoma surgery was performed.
• People whose glaucoma diagnosis is confirmed by both visual field test results and matching changes seen at the back of the eye (the optic nerve head).
• Women who could become pregnant and are willing to use a suitable method of contraception during the trial.

Who may not be able to join:

• People who have a cataract in the study eye that a clinician believes is likely to need surgery within the next three years.
• People who effectively have only one functioning eye — defined as having very poor vision or significant blind spots in one or more eyes (confirm with trial site for exact definition).
• People with a known allergy or intolerance to any ingredient in the eye drops being studied.
• People who have had laser treatment for glaucoma or glaucoma surgery in the past 2 years, or cataract surgery in the past 6 months, in the study eye.
• People whose glaucoma is of a type other than open-angle, pseudoexfoliation, or pigmentary glaucoma.
• People with other eye or general health conditions that, in the investigator's opinion, might affect vision test results or the ability to complete the trial.
• People who are already using citicoline treatment, either as eye drops or taken orally or by another systemic route.
• People currently taking other treatments (topical or systemic) that may have a similar protective effect on the optic nerve, who are not willing to stop those treatments and complete a 6-month washout period before the trial begins.
• People who are unable to produce reliable visual field test results, based on their last 4 visual field tests showing an error rate above 15%.
• People who are pregnant or currently breastfeeding.

Important: Always verify eligibility with the trial site directly before applying.