Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For younger and older adults without memory or thinking problems:

• Adults aged 18 to 35 years old (younger adults) or aged 55 and older (older adults)
• People who show no signs of cognitive (thinking or memory) impairment, based on a standard memory test called the MoCA
• People who are willing and able to agree to take part after the study has been fully explained to them
• People who are willing to follow all study requirements

For people with Mild Cognitive Impairment (MCI — early-stage memory problems):

• Adults aged 55 and older
• People who have been formally diagnosed with MCI by a doctor
• People whose diagnosis will be reviewed and confirmed by the study's medical doctor
• People who score 18 or above on a standard memory and thinking test called the MMSE (or 21 and above for mild Alzheimer's disease)
• People who score 0.5 or above on a standard scale used to measure memory-related decline (called the CDR)
• People who have a history of, or currently experience, difficulties with personal memories (remembering events from their own life)
• People who have been on a stable, unchanged dose of memory-related medications — such as donepezil, rivastigmine, or memantine — for at least 6 weeks in a row
• People who have completed at least up to Year 8 of schooling (or equivalent)
• People who score above 18 on the MoCA test, to help confirm they are able to meaningfully agree to take part
• People who are willing and able to follow all study requirements

Who may not be able to join:

For younger and older adults without memory or thinking problems:

• People who score below 26 on the MoCA memory test, which may suggest some cognitive difficulty
• People who have a major mental health condition, such as major depression, schizophrenia, or psychosis
• People who are blind or have other physical difficulties that would prevent them from completing the study tasks
• People who cannot have an MRI scan for any medical reason
• People who have any metal in their brain, skull, or body — unless a doctor has confirmed it is safe to proceed (for example, an MRI-compatible joint replacement; standard dental fillings are generally not an issue)

For people with Mild Cognitive Impairment (MCI):

• People under 55 years of age
• People who currently have a major psychiatric diagnosis, such as schizophrenia, bipolar disorder, or major depressive disorder
• People who have any other progressive or inherited neurological condition (such as Parkinson's disease or multiple sclerosis), or an acquired neurological condition (such as a stroke, brain injury, or brain tumour), in addition to MCI
• People who have had a head injury that caused a prolonged loss of consciousness
• People who currently experience poorly controlled headaches, including those regularly taking medication to prevent migraines
• People who have had unexplained fainting episodes that may have been seizures
• People who have a history of seizures or epilepsy, or who have a parent or sibling with epilepsy — unless a specialist neurologist has determined there was a single seizure with a harmless cause (such as a childhood fever)
• People who have an unstable or poorly controlled medical condition that could become dangerous if a seizure were to occur (such as certain heart conditions or asthma)
• People who have any factors that would make a brain stimulation procedure called tACS unsafe — including a seizure within the past two years, use of certain medications that affect the brain, or having certain implanted medical devices such as a deep brain stimulator, pacemaker, cochlear implant, or medication pump — or who have an active skin condition such as eczema on the scalp
• People who cannot have an MRI scan or receive tACS brain stimulation for any medical reason
• People who have any metal in their brain, skull, or body — unless a doctor has confirmed it is safe (dental fillings are generally not an issue)
• People who have implanted devices such as a pacemaker, medication pump, nerve stimulator, TENS unit, or a brain fluid shunt — unless a doctor has confirmed it is safe to proceed

Important: Always verify eligibility with the trial site directly before applying.