Phase 1 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with an advanced or spreading solid tumour (such as colorectal cancer, triple-negative breast cancer, melanoma, or ovarian cancer) that cannot be surgically removed, and your cancer has continued to grow despite standard treatments, you cannot tolerate standard treatments, or no effective standard treatment exists for you
• You have at least one measurable tumour that can be tracked during the trial
• You are able to carry out basic daily activities with little to no limitation (your doctor can confirm this using a standard scale)
• Your doctors expect you to live for at least 3 more months
• Your major organs (such as liver, kidneys, and heart) are functioning well enough, based on blood tests and other checks
• If you are a woman who could become pregnant, you must have a negative pregnancy blood test within 7 days before starting treatment
• If you could become pregnant, or your partner could become pregnant, you must agree to use effective birth control from the time you join the trial until 6 months after your last dose of study treatment

Who may not be able to join:

• You have an active tumour or cancer spread in your brain or spinal cord
• You have a history of serious ongoing or active infections
• You have a history of active autoimmune disease, or you are currently taking steroid medicines above a certain dose, or other immune-suppressing medicines within the past 14 days
• You have a history of serious lung inflammation or scarring of the lungs
• You have a history of significant heart problems (confirm with trial site)
• You have previously had a bone marrow transplant, stem cell transplant, or any solid organ transplant
• You have another cancer that is still active or has required treatment within the past 3 years (some skin cancers and localised prostate cancer that have been successfully treated may be exceptions — confirm with trial site)
• You have a condition that significantly weakens your immune system, such as a primary immune deficiency disorder or an active opportunistic infection
• You have uncontrolled fluid build-up around your lungs, heart, or abdomen that needs to be drained regularly (once a month or more)
• You have previously received certain specific treatments targeting proteins called PVRIG, TIGIT, or CD96 at any time
• You have received chemotherapy, targeted therapy, immunotherapy, or other cancer treatments within the past 28 days (or within 5 half-lives of the drug, whichever is shorter)
• You have had radiation therapy within the past 4 weeks (a single palliative dose may be an exception — confirm with trial site)
• You have taken part in another clinical trial and received an experimental treatment within the past 4 weeks
• You have taken certain immune-boosting drugs (such as thymosin, IL-2, or interferon) within the past 14 days
• You have received a live vaccine within the past 4 weeks
• You have had major surgery within the past 4 weeks, or are expected to have major surgery during the trial
• Side effects from previous cancer treatments have not yet fully resolved or returned to a manageable level (with exceptions for hair loss and skin darkening)
• You experienced severe immune-related side effects (grade 3 or higher) from previous immunotherapy, or had to stop immunotherapy because of immune-related side effects
• You have a known psychiatric condition or substance use disorder that might make it difficult to follow the trial requirements
• You are currently pregnant or breastfeeding (women who stop breastfeeding before starting the study and do not plan to restart may be eligible — confirm with trial site)
• You have a known allergy to any ingredient in the study drugs
• You have any other condition or situation that, in your doctor's judgement, would make participating in this trial unsuitable or unsafe for you
• You are unwilling or unable to follow the trial's procedures and rules
• You have a known reason why you cannot receive a type of immunotherapy drug called a PD-1/PD-L1 antibody (this applies to one specific part of the trial only — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.