Schizophrenia Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed (using DSM-5 criteria) with one of the following: schizophrenia, schizophreniform psychosis, psychosis not otherwise specified, brief psychosis, schizoaffective syndrome, or delusional disorder — and whose psychotic symptoms and decline in day-to-day functioning began no more than 3 years before joining the study (Early Psychosis group)
• People who have been assessed using a specialised interview tool (called SIPS) and identified as being at clinical high risk of developing psychosis (High Risk group)

Who may not be able to join:

• People (in the Early Psychosis or High Risk groups) whose main psychiatric diagnosis is considered to be the cause of their psychotic symptoms — for example, bipolar disorder, major depressive disorder, or autism
• People (in the Early Psychosis or High Risk groups) who have been taking benzodiazepine medications daily for more than two weeks and would be unable to pause that treatment during the study's testing procedures
• People joining as healthy comparison participants who have ever been diagnosed with a major psychiatric disorder, including substance use disorders
• People joining as healthy comparison participants who have a parent, sibling, or child with a history of a psychotic disorder or bipolar disorder
• People with a significant physical health condition, or a past or current condition affecting the brain (such as a brain tumour, neuroinflammatory disease, epilepsy, or significant brain injury), based on medical history, physical signs, MRI, or lab results
• People who have been exposed to a radiation dose of 25 mSv or more in the past year
• Women who are pregnant, breastfeeding, or lactating
• People who are not sufficiently proficient in Swedish, or who have a documented intellectual disability that would prevent them from giving informed consent
• People who meet the DSM-5 diagnostic criteria for a substance use disorder (not including nicotine dependence), or who have repeated positive drug screening results during the study
• People with a metallic object in the eye, ferro/electromagnetic implants, or a history of claustrophobia during MRI scans
• People who have had symptoms of a severe bacterial, fungal, or viral infection with whole-body effects (such as fever) within the 7 days before joining
• People who have taken blood-thinning medications within 2 weeks before certain study procedures (lumbar puncture and arterial line placement) at either the start of the study or the one-year follow-up
• People who have donated blood (one unit or more) within the past 90 days, donated plasma within the past week, or donated platelets within the past 6 weeks before screening
• People considered unsuitable for other reasons at the discretion of the study investigator or sponsor — this may include very severe symptoms or signs of aggression or hostility

Important: Always verify eligibility with the trial site directly before applying.