Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between 55 and 90 years of age (inclusive)
• People who have a parent or sibling who had Alzheimer's disease
• People whose score on a standard memory and thinking test (called the MMSE) is 27 or higher, or within the normal range when adjusted for their level of education
• People who show no signs of dementia on a standard clinical rating scale (a score of 0) at the start of the study
• People whose score on a specific memory recall test falls within the normal range, either by the standard scoring or when adjusted for education level
• People who have low levels of a protein called amyloid in their blood at the start of the study
• People who have a certain level of amyloid build-up in the brain, detected by a specialised brain scan (PET scan), falling within a specific range at the start of the study
• People who are willing and able to have MRI and PET brain scans
• People with sufficient vision and hearing to complete thinking and memory tests
• People who are able, in the opinion of the trial doctor, to complete memory and thinking tests and other study tasks
• People who are willing to complete all assessments at the start and take part in the full 13-month study
• People who are willing to provide blood samples at set times, and willing to consider providing spinal fluid samples at set times if asked

Who may not be able to join:

• People for whom MRI scans are not safe, such as those with pacemakers, aneurysm clips, artificial heart valves, ear implants, or metal fragments or foreign objects in the eyes, skin, or body
• People with severe short-sightedness (worse than -7 diopters) or untreated cataracts that affect their vision
• People with a significant ongoing illness or unstable health condition that could make it difficult to follow the study plan
• People who have a history of bleeding disorders or low platelet levels in their blood — this applies specifically to those who agree to provide spinal fluid samples
• People currently taking a type of medication called NMDA antagonists
• People taking warfarin or similar blood-thinning medications — this applies specifically to those who agree to provide spinal fluid samples
• People with a history of seizures or a diagnosis of epilepsy
• People who are currently pregnant or breastfeeding
• People with a history of severe allergic reactions or anaphylaxis
• People with a long history (more than 10 years) of ongoing alcohol or substance misuse that continued up to the time their symptoms first appeared
• People who have a brain or nervous system condition known to cause thinking or memory problems
• People with kidney disease
• People whose MRI scan shows findings such as stroke, brain tumour, or significant abnormalities (such as fluid build-up in the brain, bleeding, malformations, or a condition called cerebral amyloid angiopathy) that, in the trial doctor's opinion, would affect the study results
• People whose blood test results (if already known — the trial does not carry out its own testing) suggest a condition such as kidney disease
• People whom the trial doctor does not believe can complete enough of the key study tasks — though exceptions may be considered case by case by the Project Director

Important: Always verify eligibility with the trial site directly before applying.