Phase 1 Crohn's Disease and Colitis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with active ulcerative colitis (UC) that is currently causing symptoms at a moderate level or above, based on a standard scoring system used by doctors.
- If you are sexually active and could potentially father or carry a child, you must agree to use an effective form of birth control throughout the study.
- If you are a woman who could become pregnant, you must have a negative pregnancy test at the start of the study and again before your first treatment dose.
- You are willing and able to sign a consent form and attend all required clinic visits, check-ins, and follow-up calls.
- You have a regular doctor who will manage your general UC care outside of this trial.
Who may not be able to join:
- Your ulcerative colitis is classified as severe based on a doctor's scoring tool (confirm with trial site).
- You are unable to receive an enema that needs to be held in, or unable to swallow multiple capsules.
- You are currently pregnant, breastfeeding, or planning to become pregnant during the study.
- You have taken antibiotic tablets or injections (not creams or topical treatments) within the past 14 days before starting treatment.
- You currently have an active HIV, Hepatitis B, or Hepatitis C infection.
- You have had a recurring C. difficile (a type of gut bacterial infection) or have received a fecal microbiota transplant (FMT) in the past 6 months.
- You have another active gut condition, such as irritable bowel syndrome, celiac disease, or certain bowel surgeries, among others (confirm full list with trial site).
- You have a known history of bile acid diarrhea (a specific type of diarrhea caused by bile salts — confirm with trial site).
- Your immune system is weakened, either due to a medical condition or because you are taking immune-suppressing medications above a certain dose (confirm with trial site).
- You have or have had an active cancer and/or are currently undergoing chemotherapy, unless your cancer is minor and non-spreading, or you are on a maintenance chemotherapy plan.
- You have taken part in another medical research study involving an experimental drug within the last 90 days.
- You have a serious ongoing health condition that, in the study doctor's judgment, could interfere with your participation in the trial.
- Your life expectancy is less than one year.
- Your blood test shows a very low level of a type of infection-fighting white blood cell called neutrophils (confirm with trial site).
- The study doctor believes, for any reason, that you should not participate.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Herbert L DuPont, MD, The University of Texas Health Science Center, Houston
Phone: 713 500 6687
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Disease severity as assessed by the Partial Mayo Score (PMS) for Ulcerative Colitis (UC); Change in fecal microbiota diversity and genera as assessed by sequencing; Change in proportion of antibody-coated microbiota as assessed by the antibiotic susceptibility test; Safety as assessed by the adverse events; Safety as assessed by the adverse events
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.