COPD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 40 and 75 years old
• People who have been diagnosed with COPD, with breathing test results showing a specific level of airflow limitation and reduced lung function (confirm specific test values with the trial site)
• People whose COPD symptoms score at a certain level on standard symptom questionnaires, indicating a meaningful impact on daily life (confirm with trial site)
• People who have not smoked for at least 2 months before joining and who agree not to smoke for the entire duration of the trial
• People who, if they recently completed a formal lung rehabilitation program, did so at least 3 months before joining; or, if currently in a maintenance program, who agree to continue it through their 12-month follow-up
• People who have been taking standard COPD medications (in line with recognised COPD treatment guidelines) for at least 12 months before joining
• People who have received a flu vaccine in the past 12 months, or who agree to get one during the trial and annually for its duration
• People whose blood oxygen level at rest meets the minimum required level at the time of screening (confirm with trial site)
• People who are willing and able to complete all required tests, check-ins, and a patient diary throughout the trial
• People who understand the purpose of the trial, agree to take part, and are able to sign a consent form

Who may not be able to join:

• People whose body weight relative to their height (BMI) is below 18 or above 35
• People who have been diagnosed with asthma (as defined by recognised asthma guidelines)
• People who have been diagnosed with another active lung disease other than COPD (for example, active tuberculosis)
• People with a medical history of a collapsed lung (pneumothorax)
• People with a known allergy or medical reason they cannot receive the medications used during bronchoscopy or general anaesthesia, where this cannot be managed medically
• People who have had a respiratory infection or a COPD flare-up in the 4 weeks before joining
• People who have been treated with radiation or chemotherapy for cancer within the past 2 years
• People who are taking more than 10 mg per day of prednisone (or an equivalent steroid medication) at the time of joining
• People who have used opioid medications within the 3 months before joining
• People with a known disorder affecting how the digestive system moves food, or who have had surgery on the stomach, food pipe (oesophagus), or pancreas
• People who have an implanted electronic device (such as a pacemaker)
• People who have previously had lung or chest surgery, or who plan to have such surgery during the trial (including lung removal, lung transplant, or certain airway procedures)
• People who have had a heart attack in the last 6 months, or who have certain serious heart conditions identified on heart tests or assessments (confirm specifics with trial site)
• People assessed as being at high risk of high blood pressure in the lungs (pulmonary hypertension), based on heart scan results showing pressure above a certain level
• People with a lung nodule or other growth considered at high risk of being cancerous
• People with a significant lung airway condition called bronchiectasis, where airway walls are thickened and the airways are widened, causing persistent cough, mucus production, and repeated bleeding
• People for whom the trial's procedure is not considered feasible by the investigating doctor — for example, due to the shape of the airways or the severity of certain lung changes seen on a chest scan
• People with a total symptom score of 18 or above on a specific digestive symptom questionnaire used in this trial (confirm with trial site)
• People with any other disease or condition that might prevent them from completing the trial, including a life expectancy of less than 1 year
• Women who could become pregnant, unless a pregnancy test before treatment is negative and they agree not to become pregnant during the trial
• People who have taken part in another clinical trial and received an experimental treatment within the 3 months before screening

Important: Always verify eligibility with the trial site directly before applying.