Phase 2 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with prostate adenocarcinoma (a specific type of prostate cancer) confirmed by a tissue biopsy.
• Your cancer is considered high or very high risk, meaning at least one of the following applies: the tumor has grown into nearby tissue (cT3a–cT4), your Gleason score is 8–10 (Grade Group 4 or 5), or your PSA level was above 20 ng/mL before joining the study.
• You have had genetic testing (done at a certified lab) that found a harmful change (mutation) in the BRCA1 or BRCA2 gene.
• You may have already started certain hormone treatments for prostate cancer before joining, but the effects of that treatment must not last more than one month after joining, and no new hormone treatments can be started after you enroll.
• You are 18 years of age or older.
• You are able to carry out normal daily activities, or have only mild limitations (confirm with trial site regarding performance status scoring).
• You have had a full medical check-up and physical exam within the last 28 days.
• Your recent blood tests (within 28 days) show your immune cells, platelets, liver function, and kidney function are all within acceptable ranges.
• Your heart is functioning well enough; if you have a history of heart problems, your heart function must meet a minimum standard assessed by your doctor within the last 28 days.
• If you have HIV, you are on treatment and your virus levels are undetectable (tested within the last 6 months).
• If you have a history of hepatitis B, your virus levels are undetectable while on treatment (tested within 28 days).
• If you have a history of hepatitis C, you have either been successfully treated and cured, or if still on treatment, your virus levels are currently undetectable (tested within 28 days).
• If you are capable of fathering a child, you have agreed to use effective contraception during the study.
• A urologist has assessed you and determined that surgery may be possible and that the known areas of cancer could potentially be removed.
• You are willing to have biological samples (such as blood or tissue) stored for research purposes.
• You have been told about the research nature of this trial and have signed a consent form agreeing to take part.

Who may not be able to join:

• You have cancer that has spread to distant parts of the body (metastatic disease), based on standard imaging done within the last 90 days (confirm with trial site regarding specific imaging exceptions).
• You have previously had radiation therapy to the pelvic area.
• You have or have had another cancer that, in your doctor's opinion, could affect the safety or results of this trial.

Important: Always verify eligibility with the trial site directly before applying.