Phase 3 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are female
• You are between 12 and 35 years old
• You exercise less than 2 hours per week of moderate activity (such as jogging or swimming)
• You have irregular or infrequent periods, with or without taking metformin, as defined by international PCOS guidelines
• If you are under 18, your BMI is at or above the 95th percentile for your age; if you are 18–35, your BMI is 30 or higher, OR your BMI is 27 or higher AND you have at least one weight-related health condition such as high blood pressure or high cholesterol
• Your weight has stayed within 5 kg (about 11 lbs) of the same weight for the past 3 months
• You have been diagnosed with PCOS based on specific medical criteria, including irregular periods and higher-than-normal testosterone levels
• You are not using hormonal birth control and are willing to either avoid sex or use non-hormonal contraception (such as a copper IUD) for the entire study
• If joining the metformin + semaglutide group, you have been taking at least 1,500 mg of metformin daily for at least 3 months before the study screening

Who may not be able to join:

• You or a close family member has been diagnosed with a specific type of thyroid cancer (medullary thyroid carcinoma) or a related condition called Multiple Endocrine Neoplasia type 2 (MEN2), or a thyroid nodule was found during your screening exam (confirm with trial site)
• You are currently taking certain medications that affect how your body handles blood sugar, including some steroids, certain antipsychotics, immune-suppressing drugs, HIV medications, hormonal contraceptives, weight loss medications, or other GLP-1 medications (specific timing restrictions apply — confirm with trial site)
• You have used weight loss medications in the past 6 months
• You are currently pregnant or breastfeeding
• You have been seriously ill and needed to be hospitalised in the past 60 days
• You have diabetes, based on a specific blood test result (HbA1c of 6.5% or higher)
• You have anaemia, based on a specific blood test result (confirm with trial site)
• You have a significant psychiatric or developmental condition that would make it difficult to give informed consent
• You have a known liver disease (other than fatty liver disease), or your liver test results are significantly elevated
• You have a personal history of pancreatitis (inflammation of the pancreas)
• You have known kidney disease, or your kidney function test result is below a certain level
• You have a history of serious digestive conditions such as gastroparesis (slow stomach emptying)
• You have a history of gallstones
• You have a thyroid condition that is not being treated
• You have had an allergic reaction to semaglutide in the past
• Your high testosterone or irregular periods are caused by something other than PCOS, such as a tumour or another hormonal condition
• You are currently being treated for or are experiencing active symptoms of anorexia nervosa or a binge/purge eating disorder
• You are hoping to become pregnant within the next 12–18 months
• You have previously had bariatric (weight loss) surgery
• You use THC (cannabis, whether smoked or eaten) more than 3 days per week
• You drink more than 2 alcoholic drinks on more than 3 days per week
• You are unwilling or unable to commit to using appropriate non-hormonal contraception throughout the study

Important: Always verify eligibility with the trial site directly before applying.