Phase 3 Breast Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older at the time of signing the consent form
• People who have been confirmed, through a tissue sample tested by a local lab, to have breast cancer that is estrogen-receptor positive and/or progesterone receptor positive
• People whose breast cancer has tested negative for HER2 (a specific protein), based on standard lab testing methods on the most recently analysed tissue sample
• People who have already started standard hormone-blocking therapy (such as tamoxifen or toremifene) before joining, as long as they started it no more than 36 months ago and still have at least 3 years of that treatment remaining
• People who have had surgery where the tumour was completely removed, with no cancer cells found at the edges of the removed tissue, and whose cancer falls into a specific stage category (Stage IIB, a subset of Stage IIA, or Stage III — confirm exact staging eligibility with the trial site)
• People with a general health/activity level rated as 0, 1, or 2 on a standard medical scale (meaning able to carry out daily activities, with or without some limitations)
• People with adequate bone marrow and organ function, as assessed by the trial team
• People whose heart electrical activity readings (from an ECG) fall within acceptable ranges — specifically, a certain heart rhythm measurement below 450 milliseconds and a resting heart rate between 50 and 99 beats per minute

Who may not be able to join:

• People whose breast cancer has spread to distant parts of the body (Stage IV), or who have had their cancer return after surgery
• People currently receiving other cancer treatments, apart from hormone-blocking therapy
• People with other serious or poorly controlled health conditions that, in the doctor's judgement, could make participation unsafe, interfere with the study, or where life expectancy is estimated at 5 years or less
• People with significant, uncontrolled heart disease or abnormal heart rhythm
• People who are pregnant, breastfeeding, or planning to become pregnant or breastfeed during the trial
• Women who are physically capable of becoming pregnant, unless highly effective contraception is used throughout the treatment period and for 21 days after stopping the study treatment

Note: Other eligibility criteria not listed here may also apply.

Important: Always verify eligibility with the trial site directly before applying.