Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older (there is no upper age limit)
• People showing signs consistent with an acute ischemic stroke (a stroke caused by a blood clot blocking blood flow to the brain)
• People with a stroke severity score above 5 at the time of enrolment, where the last time they were known to be well was within the past 23 hours — or people with symptoms that have been coming and going, or gradually getting worse, over the last 7 days
• People whose ischemic stroke has been confirmed by a brain scan (CT or MRI), or whose scan appears normal but a stroke is still suspected
• People whose brain scan shows a specific pattern suggesting a portion of the brain is at risk but not yet fully damaged, meeting certain size and ratio thresholds (confirm with trial site for exact technical details)
• People whose imaging (CT or MRI angiography) shows a complete blockage of the internal carotid artery in the neck, from any cause (such as a tear in the artery wall, plaque build-up, or unknown cause), without a related blockage of a large artery inside the skull, confirmed within 1 hour before enrolment
• People for whom the procedure to treat the blockage is expected to be able to start within 60 minutes of enrolment
• People who were able to live independently or with only minor limitations before the stroke (pre-stroke disability score of 2 or less out of 5)
• People, or their legal representative, who have been informed about the study and have given signed consent, or who meet the criteria for emergency consent

Who may not be able to join:

• People who had a surgical procedure to clear their carotid artery (endarterectomy) within the past month
• People with serious or life-threatening other health conditions, or a life expectancy of less than 6 months, where the procedure is unlikely to be of benefit
• People who would be unable to attend follow-up appointments
• People with a pre-existing neurological or psychiatric condition that would make it difficult to accurately assess stroke-related symptoms
• People who had a seizure at the start of the stroke, if it makes the stroke diagnosis uncertain or prevents an accurate baseline assessment
• People where a disease affecting the blood vessels of the brain (such as inflammation of the blood vessels) is suspected based on medical history or imaging
• People who are currently pregnant, planning to become pregnant during the study period, or who are breastfeeding at the time of admission
• People who are legally protected adults or under guardianship (confirm with trial site)
• People currently taking part in another clinical trial of an investigational medicine or device
• People who are not affiliated with or covered by the French social security system
• People with a known life-threatening allergy to contrast dye or endovascular products used in the procedure
• People who also have a narrowing of 50% or more in the middle cerebral artery on the same side as the carotid blockage
• People whose carotid artery was already known to be blocked 30 or more days before enrolment, or where the blockage is strongly suspected to be long-standing based on history or imaging
• People who have both a neck carotid artery blockage and a large artery blockage inside the skull at the same time
• People with a previous stent already placed in the affected carotid artery
• People with a stent already in a brain artery in the same area as the carotid blockage
• People where the carotid artery is severely narrowed but not fully blocked (sub-occlusive stenosis) on imaging
• People where the blockage is suspected to start in a deeper portion of the carotid artery (inside the skull or at the base), while the neck portion appears normal on imaging
• People with no usable vascular access point for the procedure
• People where an aortic dissection (a tear in the main artery from the heart) is suspected based on history, examination, or imaging
• People where the common carotid artery (a different artery in the neck) is blocked but the internal carotid artery is not
• People whose brain scan shows any sign of bleeding in the brain

Important: Always verify eligibility with the trial site directly before applying.