Phase 2 Alopecia Areata Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 6 and 17 years old, and a parent or legal guardian is able to sign the consent forms on your behalf.
• You are able to attend all required study visits and follow the study schedule.
• If you are a girl who could potentially become pregnant, you must have a negative pregnancy test at the start of the study and agree to use an approved form of birth control during the study and for at least 28 days after the last dose of the study medicine.
• You have had moderate to severe hair loss (alopecia areata) covering at least 50% of your scalp for at least 6 months, as measured by a specific scoring tool.
• You have a higher-than-normal level of a certain allergy-related protein in your blood (IgE ≥ 200), and/or you or a family member have a history of allergic conditions such as asthma, eczema, hay fever, food allergies, or a condition called eosinophilic esophagitis.
• Your doctor considers you to be in generally good health based on your medical history, a physical exam, and blood tests.

Who may not be able to join:

• You are unwilling or unable to give consent or follow the study rules.
• You are currently pregnant or breastfeeding.
• Your hair loss has more than one cause, or the cause is unclear — for example, if it is related to tight hairstyles, scarring, pregnancy, certain medications, or a common type of age-related hair thinning at an advanced stage.
• You have had alopecia areata for 7 or more years with no sign of any hair growing back since your last episode of hair loss.
• You have severe asthma that is not well controlled, including two or more serious asthma episodes in the past year that needed steroid treatment or a hospital stay, or you have had a life-threatening asthma attack even while on asthma medication.
• You currently have an active bacterial, viral, or parasitic infection, or you have a history of serious infections that keep coming back and require antibiotic treatment.
• Your doctor believes your immune system is weakened or not working properly.
• You have a serious, ongoing, or hard-to-control condition affecting your kidneys, liver, blood, digestive system, metabolism, hormones, lungs, heart, or nervous system.
• You have active hepatitis B, hepatitis C, or HIV, or you test positive for HIV and your doctor considers you to be at high risk for the disease.
• You have, or are suspected to have, a blood or lymph system cancer, or you have had any cancer in the past 5 years (except for certain fully treated, non-spreading skin or cervical cancers).
• You received a live vaccine within 28 days before being assigned to a treatment group in the study.
• Your doctor believes there are other medical reasons that could put you at risk or affect the study results (confirm with trial site).
• You have had a serious allergic or bad reaction to any ingredient in the study drug in the past.
• You have used certain immune-suppressing medicines — including cyclosporine, steroid injections, methotrexate, JAK inhibitor tablets, or UV light therapy — within 4 weeks before the start of the study.
• You have previously been treated with a medicine called dupilumab.
• You have used certain skin creams or ointments (such as steroid creams, tacrolimus, or pimecrolimus) within 1 week before the start of the study.

Important: Always verify eligibility with the trial site directly before applying.