Phase 1 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be at least 18 years old at the time of signing the consent form.
• You must be able to understand and sign a consent form agreeing to take part in the study.
• You must have been diagnosed with one of these cancer types: non-small cell lung cancer, colorectal cancer, head and neck cancer, pancreatic cancer, breast cancer, ovarian cancer, or another type of solid tumor cancer.
• Your tumor must have a specific genetic change called "TP53 R175H," and you must have a particular immune system marker called "HLA-A*02:01," both confirmed by an approved laboratory test.
• Your cancer must be advanced, meaning it cannot be surgically removed and/or has spread, and you must have already tried at least one standard approved cancer treatment with no curative options remaining.
• You must have at least one area of cancer that can be measured on a CT scan or MRI.
• You must be generally well enough to carry out daily activities with little to no limitation (confirm with trial site).
• Your blood counts, kidneys, liver, lungs, and heart must be functioning well enough as determined by tests.
• The study team must believe you are likely to attend all required visits and follow the study rules.

Who may not be able to join:

• You have been diagnosed with another separate cancer within the past 3 years (exceptions may apply for certain skin cancers, some very early-stage cancers, or low-grade prostate cancer — confirm with trial site).
• You have an active cancer that has spread to or started in the brain or spinal cord.
• You have previously received a type of treatment involving genetically modified cells, a stem cell transplant from a donor, or an organ transplant.
• You have had a stroke or mini-stroke in the past 12 months.
• You have had a serious heart condition in the past 6 months, or have ever been diagnosed with heart failure.
• You have received cancer treatment within approximately 2 weeks before enrolling (the exact timing depends on the treatment — confirm with trial site).
• You have had a severe allergic reaction to certain medications used in this trial (cyclophosphamide, fludarabine, or rIL-2), or are known to be allergic to methotrexate, gentamicin, or similar antibiotics.
• You have a condition where your immune system does not work properly from birth (primary immunodeficiency).
• You have received a live vaccine within 4 weeks before enrolling, or plan to receive one before starting treatment in the trial.
• You have an active autoimmune or immune-related disease that requires steroids or other immune-suppressing medications (with some exceptions — confirm with trial site).
• You are currently breastfeeding or producing breast milk at the time of enrollment.
• You have been diagnosed with, or have close family members diagnosed with, a hereditary condition called Li-Fraumeni syndrome.

Important: Always verify eligibility with the trial site directly before applying.