Phase 2 Chronic Rhinosinusitis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are an adult (aged 18 to under 80) who has been diagnosed with chronic rhinosinusitis (a long-term sinus condition) by an ear, nose and throat (ENT) specialist.
• You are currently receiving the maximum recommended medical treatment for your sinus condition as part of your normal care.
• You have had sinus surgery (called FESS – a procedure to open up the sinuses using a small camera) at least 6 months before joining the study.
• A camera examination of your nose has shown that any nasal polyps (small growths inside the nose) are small to moderate in size — not completely blocking your nasal passage.
• The examination has confirmed that key parts of your sinuses are visible and accessible for treatment.
• You rate your condition as more than 2 out of 10 on a symptom severity scale at the time of screening.
• You weigh at least 40 kg and have a BMI of 39 or below at the screening visit.
• If you are able to become pregnant, you must be willing to use a reliable form of contraception and not plan to become pregnant during the study.
• You are willing and able to give written consent and follow all study requirements.

Who may not be able to join:

• You have a known allergy or sensitivity to betamethasone dipropionate, mometasone, or local anaesthetic agents (medicines used in this treatment).
• You have nasal or sinus abnormalities, other nasal conditions, or implanted devices in the nose/sinuses that would prevent the treatment from being given.
• You have previously taken part in this same study.
• You are currently taking, or have taken in the past 4 weeks, steroid tablets or injections that work throughout your whole body, or you are currently receiving biologic therapy (a type of medication that targets specific parts of the immune system).
• You have a history of glaucoma or cataracts, or your eye pressure was found to be higher than normal (above 21 mmHg) at your screening appointment.
• You currently have an acute (sudden or severe) sinus infection.
• You have a known problem with your immune system that reduces your ability to fight infections.
• You have Type 1 diabetes.
• You have cystic fibrosis.
• You are pregnant, trying to become pregnant, or currently breastfeeding, as the effects of this treatment on pregnancy are not yet known.
• You are unable to give informed consent due to mental illness, dementia, or difficulties with communication.
• You have been diagnosed with Cushing's disease (a hormonal condition) within the past 12 months.
• You have a severely deviated nasal septum (a significant bend in the wall between your nostrils) or have had a complete removal of a specific nasal structure called the middle turbinate.
• You have any abnormal test results or other health conditions that the study doctor feels would make participation unsuitable (confirm with trial site).
• The study doctor believes you are unlikely to be able to follow all study procedures and requirements.

Important: Always verify eligibility with the trial site directly before applying.