Chronic Rhinosinusitis

**Who might be able to join this trial:** - You have nasal polyps in both nostrils, and despite previous treatment with steroid tablets/pills at any point in the last 2 years, your polyps are still present — or you were unable to take steroid pills due to a medical reason, or you have had surgery for nasal polyps in t...

**Who might be able to join this trial:** - Adults aged 18 years or older at the time of their first study visit. - Women who could become pregnant must either be abstaining from sex, or using an effective form of birth control (such as the pill, contraceptive injections, a patch, an intrauterine device, a double-barr...

**Who might be able to join this trial:** - You have been diagnosed with chronic sinusitis (CS). - You have already tried at least two different medical treatments for chronic sinusitis in the past. - Your chronic sinusitis symptoms meet a minimum level of severity required by the trial. - You are able to tolerate numb...

**Who might be able to join this trial:** - You have been diagnosed with chronic rhinosinusitis (long-term inflammation of the sinuses). - You have previously had a specific sinus surgery called a bilateral total ethmoidectomy (a complete surgery on the sinus cavities on both sides of the nose). - A CT scan (a type of...

**Who might be able to join this trial:** - You are an adult (aged 18 to under 80) who has been diagnosed with chronic rhinosinusitis (a long-term sinus condition) by an ear, nose and throat (ENT) specialist. - You are currently receiving the maximum recommended medical treatment for your sinus condition as part of yo...

**Who might be able to join this trial:** - You are a man or woman between 18 and 75 years old - You have been using a nasal corticosteroid spray regularly and consistently for at least 4 weeks before joining, and are willing to continue using it throughout the study - You have previously been treated with steroid tab...

**Who might be able to join this trial:** - You are between 15 and 70 years old. - You have had a blocked nose on more than half of days over the last 3 months, lasting at least 12 weeks in a row. - You have had a runny nose on more than half of days over the last 3 months, lasting at least 12 weeks in a row. - An ear,...

**Who might be able to join this trial:** - The child must be between 4 and 17 years old and generally healthy - The child must have a history of recurring or long-lasting sinus problems - The child must have had more than 3 months of symptoms such as a stuffy nose, nasal discharge, persistent daytime cough, mucus drip...

Who might be able to join this trial: - You are an adult who is able to carry out normal daily activities on your own Who may not be able to join: - You currently have signs or symptoms of a sinus infection or ongoing sinus problems - You have had surgery on your sinuses in the past - You have a deviated septum (a cro...

**Who might be able to join this trial:** - You are 18 years of age or older and have been diagnosed with long-term (chronic) sinusitis affecting the maxillary sinuses (cheek sinuses) or both the cheek sinuses and nearby ethmoid sinuses. - You have had a CT scan taken after trying treatments such as antibiotics or nasa...

Who might be able to join this trial: - You have symptoms of chronic rhinosinusitis (long-term sinus problems such as congestion, facial pain, or difficulty breathing through your nose), but a physical exam and camera examination of your nasal passages appear normal Who may not be able to join: - You are pregnant - Yo...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with chronic sinusitis (long-term sinus problems) - Your doctor has recommended a type of sinus surgery called FESS (a minimally invasive procedure to clear the sinuses) and you have agreed to have it - A CT scan (a d...

**Who might be able to join this trial:** **Group 1 (People with a healthy immune system and chronic sinus problems):** - You are 18 years of age or older - You have been experiencing chronic rhinosinusitis (long-term sinus problems) for 12 weeks or more, even after receiving medical treatment - You have at least 2 of...

**Who might be able to join this trial:** - Children between the ages of 2 and 18 years old - Both boys and girls are eligible - Children who are scheduled to have a sinus-related surgical procedure (such as endoscopic sinus surgery, removal of the adenoids, or a sinus wash to collect a sample), as recommended by the d...

**Who might be able to join this trial:** - You must be male or female and at least 18 years old. - If you are a woman who could become pregnant, you must be using an approved form of birth control (such as the pill, injection, implant, condom, IUD, or have had your tubes tied); women who have had a full hysterectomy...

Who might be able to join this trial: - You have had a reduced sense of smell and a blocked nose for more than 12 weeks - You have nasal polyps (small, non-cancerous growths) inside both nostrils - Your doctor has determined that you are a suitable candidate for surgery Who may not be able to join: - You have a weaken...

**Who might be able to join this trial:** - You have long-term sinus inflammation on both sides of your face (lasting at least 8 weeks in a row), confirmed by a CT scan - Your doctor has recommended and you have agreed to a type of sinus surgery called FESS (a procedure to open and clear blocked sinuses) - Your FESS su...

Who might be able to join this trial: - You are 18 years of age or older - You have a condition affecting your maxillary sinus (the large sinus cavity located behind your cheekbones) - You have chronic sinusitis (long-lasting inflammation or infection of the sinuses) Who may not be able to join: - You have a fungal in...

Who might be able to join this trial: - You are having surgery to treat chronic sinus problems (with or without nasal polyps) - Your surgery is expected to last at least 2 hours - At least 3 of your sinuses are affected and will be treated during the surgery Who may not be able to join: - You have had an allergic reac...

Who might be able to join this trial: - You are a male or female aged 19 or older - You have been diagnosed with a long-term sinus condition called Chronic Rhinosinusitis (CRS) - Treatments you have already tried for your sinuses have not worked well enough - Scans or imaging have shown signs of inflammation in your si...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with chronic sinusitis (long-term inflammation of the sinuses) - You have had surgery to remove tissue from both sides of your sinuses (called bilateral total ethmoidectomy), and this surgery was done at least 90 day...

Who might be able to join this trial: - You are an adult (18 years or older) - You have a condition called Aspirin-exacerbated respiratory disease, which means your breathing symptoms get worse when you take aspirin or similar pain medications Who may not be able to join: - You have taken Prednisone or other steroid t...

Who might be able to join this trial: - You have been diagnosed with chronic rhinosinusitis (long-term inflammation or infection of the sinuses) - You are 18 years of age or older - You are able to speak and communicate in English Who may not be able to join: - You are currently pregnant or breastfeeding - You have a...

**Who might be able to join this trial:** - You have been diagnosed with chronic sinusitis (long-term inflammation or infection of the sinuses) as defined by recognised medical guidelines - Your doctor has decided you need surgery because your symptoms have not improved after trying the maximum level of medical treatme...

**Who might be able to join this trial:** - You have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation) with nasal polyps graded as level I, II, or III - You have a minimum level of airflow measurable through each side of your nose separately (confirmed by a specific breathing test called PNIF sh...

**Who might be able to join this trial:** - You have been officially diagnosed with chronic rhinosinusitis (long-term inflammation of the sinuses) - Surgery on your sinuses is currently the only other option available to you - You are willing and able to give written consent before any tests or study procedures begin...

**Who might be able to join this trial:** - You have had sinus symptoms lasting at least 12 weeks, or you get sinus infections more than 3 times a year - You have already tried antibiotics for at least 3 weeks, plus nasal steroid sprays or antihistamines for at least 3 months, and saline nasal rinses, but these treatme...

**Who might be able to join this trial:** - You have been diagnosed with chronic rhinosinusitis (long-term inflammation of the sinuses and nasal passages), either with or without nasal polyps, based on recognised medical guidelines - You are between 16 and 70 years old - You are Chinese - Your condition has not improve...

**Who might be able to join this trial:** - You are an adult who has had a type of sinus surgery (called FESS) to treat chronic sinusitis with nasal polyps, and your surgery took place within the study's timeframe. **Who may not be able to join:** - You are under 18 years old. - You are currently taking oral steroids...

Who might be able to join this trial: - You are between 18 and 70 years old - You are willing to use effective birth control during the study and for 1 month after the last dose (if female) or 3 months after the last dose (if male) - You have been officially diagnosed with chronic sinusitis with nasal polyps - Your med...

Who might be able to join this trial: - You have been diagnosed with chronic rhinosinusitis (long-term inflammation or infection of the sinuses) - You are scheduled to have endoscopic sinus surgery (a procedure using a small camera to treat the sinuses) Who may not be able to join: - You are under 18 years of age - Yo...

**Who might be able to join this trial:** - You are 18 years of age or older. - You are willing and able to follow the study's requirements and attend follow-up visits. - You have been diagnosed with chronic sinusitis (long-term inflammation of the sinuses and nasal passages) confirmed by a CT scan, with symptoms last...

Who might be able to join this trial: - You are between 2 and 21 years old - You have been diagnosed with Chronic Rhinosinusitis (a long-term condition where the sinuses are inflamed or blocked) - Your doctor has suggested you may be a suitable candidate for a procedure where a small balloon is used inside the nose to...

Who might be able to join this trial: - You are 18 years of age or older. - You have long-term sinus problems (chronic rhinosinusitis) that have not improved with medication or previous sinus surgery. - You are scheduled to have surgery on at least one of certain sinus openings (the frontal, sphenoid, or maxillary sinu...

**Who might be able to join this trial:** - You have had at least 12 weeks of symptoms that include at least 2 of the following: a blocked nose, discharge from the nose or mucus dripping down the back of your throat, pain or pressure in your face, or a reduced sense of smell. - You have tried at least 2 treatments for...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with chronic sinusitis with nasal polyps, meaning you have had symptoms for at least 12 weeks - You have at least 2 of the following symptoms: mucus dripping from the front or back of the nose, a blocked nose, or pain...

**Who might be able to join this trial:** - You have had at least two of the following symptoms for 12 weeks or longer: mucus dripping from the front or back of your nose, a blocked or congested nose, pain or pressure or a feeling of fullness in your face, or a reduced sense of smell. - A doctor has confirmed signs of...

**Who might be able to join this trial:** - You have nasal polyps in both nostrils that have not been controlled well enough, even after trying steroid tablets/pills at some point in the last 2 years, or you were unable to take steroids due to a medical reason or side effects, or you have previously had surgery to tre...

**Who might be able to join this trial:** - You have had ongoing sinus symptoms for at least 3 months that meet the recognized definition of chronic rhinosinusitis. - You have had a CT scan of your sinuses (either done at the clinic or taken within the last 3 weeks) showing a moderate or higher level of sinus disease,...

**Who might be able to join this trial:** - You have been diagnosed with chronic rhinosinusitis (a long-term sinus condition) and are scheduled to have sinus surgery (a procedure to improve airflow through the sinuses) - You are over 18 years old - You are able to speak and read English **Who may not be able to join:*...

**Who might be able to join this trial:** - You have agreed to participate by signing a consent form approved by an ethics review board - You are 18 years of age or older - You are willing and able to follow the study's requirements and schedule - You have been diagnosed with chronic sinusitis (long-term sinus inflamm...

**Who might be able to join this trial:** - You are between 18 and 75 years old - You have severe nasal polyps in both nostrils, confirmed by a camera examination with a score of at least 5 - A blood test shows you have a higher-than-normal level of certain immune cells called eosinophils (at least 300 per microlitre)...

**Who might be able to join this trial:** - You must be able to follow the study rules and schedule, as decided by the study doctor. - You must have already been taking part in a related study (GA39688 or GA39855), completed an endoscopy, and finished all required check-ups at the 24-week point — without stopping the s...

**Who might be able to join this trial:** - You have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation) according to recognised medical guidelines. - A CT scan taken within the last 30 days shows sinus disease affecting both sides of your frontal sinuses (the sinuses above your eyes). - A camera...

Who might be able to join this trial: - You have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation), with or without nasal polyps - You are scheduled to have sinus surgery (a procedure to clear and open the sinus passages) - You are considered generally healthy or have only a mild health conditio...

Who might be able to join this trial: - You are between 18 and 80 years old (male or female) - You have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation) - You have previously had sinus surgery through the nose (called endoscopic sinus surgery), which included at least two specific procedures on...

**Who might be able to join this trial:** - You have had two or more of the following symptoms for 12 weeks or longer: thick or discolored nasal discharge (from the front or back of the nose), a blocked or stuffy nose, pain or pressure or a feeling of fullness in your face, or a reduced sense of smell - A doctor has co...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with Chronic Rhinosinusitis (long-term sinus inflammation), with or without nasal polyps - You have previously had sinus surgery using a camera (called endoscopic sinus surgery) - Your past surgery must have included...

**Who might be able to join this trial:** - You must be willing to take part and sign a written consent form agreeing to the use of your personal information. - You must be 18 years old or older (male or female). - You must have sinus and nasal symptoms that fit one of these patterns: symptoms lasting more than 1 week...

**Who might be able to join this trial:** - People aged 18 or older at the time of signing the consent form. - People who weigh at least 40 kilograms (approximately 88 pounds). - Both men and women are eligible, provided appropriate contraception is used where required. - Women who are not pregnant or breastfeeding —...

**Who might be able to join this trial:** - You are scheduled to have a planned (non-emergency) nose or sinus operation, such as straightening the nasal septum, reducing the turbinate bones inside the nose, or endoscopic sinus surgery - You are 18 years old or older - You can speak and understand English - You are able...

**Who might be able to join this trial:** - You have been diagnosed by a doctor with chronic rhinosinusitis with nasal polyps (growths inside the nose) for at least 12 months before the first visit, and your polyps are severe enough that surgery has been considered - You have significant nasal congestion and have had...

**Who might be able to join this trial:** - You are between 18 and 70 years old (male or female) - You are willing and able to sign a consent form agreeing to take part in the study - You are able and willing to follow all study procedures and attend for the full length of the study - You have been diagnosed with chron...

**Who might be able to join this trial:** - You are 18 years of age or older. - You have nasal polyps in both nostrils, and despite past treatment with steroid tablets/pills at any point in the last 2 years, OR you could not take steroids for medical reasons, OR you have had surgery for nasal polyps, your polyps are s...

**Who might be able to join this trial:** - You are scheduled to have a functional nasal or sinus surgery using a small camera (called endoscopic sinus surgery) - You have been rated as generally healthy or having only mild health conditions by your doctor before surgery (confirm with trial site) - You are 18 years of...

**Who might be able to join this trial:** - You have had at least two episodes of moderate or severe facial pain, pressure, or fullness in the past 30 days before the screening visit. - You are willing to follow the study's rules about which medications you can take and agree not to start any new medications for sinus...

"Who might be able to join this trial: - People who have a condition called AERD (Aspirin-Exacerbated Respiratory Disease, which involves sensitivity to aspirin and related medicines along with nasal polyps and asthma) - People who have chronic rhinosinusitis with nasal polyps (a long-term sinus condition where small g...

**Who might be able to join this trial:** - You must have already completed the full treatment and follow-up period (including the final end-of-study visit) in the related lunsekimig parent study. - You must currently be using a mometasone furoate nasal spray (a type of steroid nasal spray) as part of your treatment. -...

**Who might be able to join this trial:** - You are 18 years old or older - You receive care at a USC ear, nose, and throat (ENT) clinic in Los Angeles, Glendale, La Cañada, or Arcadia - You have been diagnosed with chronic rhinosinusitis (a long-term condition causing inflammation of the sinuses and nasal passages) -...

**Who might be able to join this trial:** - You are 18 years old or older - You are scheduled to have sinus surgery on both sides of your nose (called endoscopic sinus surgery) for a chronic sinus condition, with or without nasal polyps, and your surgeon plans to fully clear out specific sinus passages on both sides at...

**Who might be able to join this trial:** - You have been diagnosed with chronic rhinosinusitis with nasal polyps (a condition where the sinuses are chronically inflamed and nasal polyps have grown), confirmed using standard medical guidelines - Your nasal polyps show a high level of a specific type of immune cell (eos...

Who might be able to join this trial: - You have been diagnosed with chronic sinusitis (long-term inflammation of the sinuses) and your doctor has determined you need a specific type of sinus surgery called a "frontal drill-out" procedure. Who may not be able to join: - You are unable or unwilling to follow the study'...

Who might be able to join this trial: - You must be 19 years of age or older - You must be scheduled to have a procedure called Endoscopic Sinus Surgery (a surgery performed through the nostrils to treat sinus problems) - You must have chronic sinusitis with nasal polyps (growths inside the nose) along with moderate-to...

Who might be able to join this trial: - You are 18 years old or older and have been diagnosed with long-term sinus inflammation affecting the frontal sinuses (the sinuses in your forehead), with or without nasal polyps, confirmed by a camera examination of your nose and a CT scan. - The condition may affect one or both...

**Who might be able to join this trial:** - You are between 18 and 65 years old, and are either male or a female who is not pregnant - You understand the purpose and steps of the trial and are willing to sign a consent form agreeing to take part - You have been diagnosed with chronic rhinosinusitis (long-term sinus inf...

**Who might be able to join this trial:** - You must be 19 years of age or older when you sign the consent form - You must be able to understand and sign a consent form agreeing to take part - You must have been diagnosed with chronic sinusitis with nasal polyps, based on symptoms and/or scans or camera examinations o...

**Who might be able to join this trial:** - You are between 18 and 75 years old - You have nasal polyps in both nostrils, diagnosed as chronic rhinosinusitis with nasal polyposis - Your nasal polyps have been scored at a certain level of severity (at least 2 in each nostril) — this will be checked at your first visit...

Who might be able to join this trial: - You must be 12 years of age or older - You must have been diagnosed with chronic rhinosinusitis (a long-term condition causing inflammation of the sinuses and nasal passages) following recognised international guidelines - You (or your legal guardian or representative) must be wi...

**Who might be able to join this trial:** *For people with sinus problems:* - You have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation) according to established medical guidelines - You have signed and dated a consent form agreeing to take part - You are scheduled to go into hospital for an en...

Who might be able to join this trial: - You have been diagnosed with chronic sinusitis without nasal polyps, based on a specific set of recognised medical guidelines - It has been at least 3 months since you had endoscopic sinus surgery (a procedure to open up the sinuses using a small camera) - You have a reduced sens...

**Who might be able to join this trial:** - You have a condition called chronic rhinosinusitis with nasal polyps (long-term inflammation in the sinuses along with growths inside the nose called polyps). - Your nasal polyps have been assessed by a doctor and scored at a certain level of severity (a total score of 5 or h...

**Who might be able to join this trial:** - You must have received at least one dose of a medicine called tezepelumab, used for its approved, officially permitted purpose in your country. - You must have signed and dated a consent form showing that you (or someone legally authorised to act on your behalf) have been ful...

**Who might be able to join this trial:** - You are between 18 and 99 years old and willing to take part in the study - You have been formally diagnosed with asthma by a doctor - You are receiving treatment for severe asthma at the highest recommended treatment levels (known as GINA/DAL step 4 or 5) - Your asthma is n...

**Who might be able to join this trial:** - You took part in an earlier related study (reference EK 1044/2020) and have continued taking Dupilumab without stopping since then (this will be based on what you report yourself, as there is no lab test to check this). - You have signed and dated a consent form agreeing to t...

Who might be able to join this trial: - You are between 25 and 50 years old. - You can be either male or female. - You have been diagnosed with chronic rhinosinusitis (long-term inflammation of the sinuses and nasal passages). - You are willing and able to give your informed consent to take part in the study. - Your CT...

**Who might be able to join this trial:** - You are between 18 and 65 years old - You have been diagnosed with chronic sinusitis (symptoms lasting 12 weeks or longer) or acute sinusitis, confirmed by an ear, nose, and throat specialist - You are willing and able to sign a consent form agreeing to take part **Who may n...

**Who might be able to join this trial:** - A camera examination (endoscopy) of your nose shows nasal polyps on both sides, with a combined score of 4 or higher (at least 2 points per side) - You have had a blocked nose for more than 3 months, with a symptom score of 2 or more out of 3, and/or a reduced sense of smell...

Who might be able to join this trial: - You are 18 years old or older and have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation), with or without nasal polyps, as confirmed by your doctor. - You have had at least 2 of the following symptoms for more than 12 weeks: blocked or stuffy nose, runny n...

**Who might be able to join this trial:** - You are able to understand the study and are willing to sign a consent form agreeing to take part - You are between 18 and 75 years old (inclusive), any gender - You have been diagnosed with nasal polyps in both nostrils, along with long-term sinus inflammation (chronic rhin...

Who might be able to join this trial: - You are 19 years old or older - You are already scheduled to have endoscopic sinus surgery (a procedure to treat sinus problems using a small camera and instruments inserted through the nose) Who may not be able to join: - You have cystic fibrosis (an inherited condition affecti...

**Who might be able to join this trial:** - You are between 18 and 65 years old and are a patient at an ear, nose, and throat (ENT) clinic with a reduced or lost sense of smell - Your reduced or lost sense of smell has been diagnosed as being linked to a chronic sinus condition, following recognised medical guidelines...

**Who might be able to join this trial:** - People aged between 18 and 75 years (inclusive) at the time of signing the consent form, of any gender - People who have been diagnosed with chronic rhinosinusitis with nasal polyps (a long-term sinus condition with polyps) in both nostrils, meeting specific Chinese clinical...

**Who might be able to join this trial:** - You must be 18 years of age or older. - You must have been diagnosed with chronic sinusitis with nasal polyps for at least 1 year. - You must have had either previous surgery on your sinuses or nose for nasal polyps, OR your sinusitis symptoms got worse and needed steroid tab...

**Who might be able to join this trial:** - You previously took part in a specific clinical study of a drug called CM512 for chronic sinusitis with nasal polyps (the study numbered CM512-102101). **Who may not be able to join:** - You have not waited long enough since your last treatment — for example, less than 10 we...

**Who might be able to join this trial:** - You are scheduled to have surgery on your nose or sinuses - If you are in the nasal polyp group: you have had at least 2 of these symptoms for 12 weeks or more — a blocked nose, a runny nose (front or back), facial pain or pressure, or a reduced/lost sense of smell — AND a do...

**Who might be able to join this trial:** - You are 19 years of age or older at the time of signing the consent form - You are able to understand and sign a consent form agreeing to take part in the study - You have been diagnosed with chronic sinusitis with nasal polyps, confirmed by symptoms and/or imaging or camera...

**Who might be able to join this trial:** - You are 18 years old or older - You are scheduled to have one of the following common ear, nose, and throat (ENT) procedures done in a clinic or doctor's office: turbinate reduction, nasal debridement, balloon sinuplasty, radiofrequency ablation (a procedure to treat nasal ti...

**Who might be able to join this trial:** - You are able to understand what the study involves and are willing to sign a consent form agreeing to take part - You are between 18 and 75 years old (any gender) - You have been diagnosed with nasal polyps in both nostrils, meeting specific Chinese medical guidelines for th...

**Who might be able to join this trial:** - You must be 18 years old or older at the time of signing the consent form. - You must have been diagnosed with chronic rhinosinusitis with nasal polyps (a long-term sinus condition where growths form in the nose) for at least 12 months before your first study visit. - You mu...

Who might be able to join this trial: - You are between 18 and 65 years old (any gender) - You have been diagnosed with a long-term sinus infection without nasal polyps (lasting more than 12 weeks), based on Chinese medical guidelines from 2018 - A camera examination of your nose has shown signs of pus or discharge in...

**Who might be able to join this trial:** - You are between 18 and 65 years old (any gender) - You have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation) according to recognised medical guidelines - Your sinus condition has lasted for more than 12 weeks - Your nasal symptoms have been measured b...

**Who might be able to join this trial:** - You have been diagnosed with chronic rhinosinusitis (a long-term sinus condition) based on specific recognised medical guidelines, with symptoms lasting at least 12 weeks in a row. - Your sinus condition shows signs of inflammation, such as discoloured nasal discharge, nasal...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with chronic sinusitis with nasal polyps that needs surgery, after already trying medication treatments recommended by Canadian sinusitis guidelines - You have nasal polyps on both sides of your nose that are at least...

**Who might be able to join this trial:** - You are 18 years of age or older - You are willing and able to give your consent to take part in the trial - You have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation) by one of the trial doctors - You have had a CT scan within the last 30 days that cl...

**Who might be able to join this trial:** - You have had endoscopic sinus surgery (a procedure to clear the nasal passages) for nasal polyps that did not get better after at least 4 months of steroid medication treatment - You are covered by social insurance (health coverage) - You are willing to follow all the steps a...

**Who might be able to join this trial:** - You are aged 18 to 69 years old - You are willing to take part in the study - You have been diagnosed with either chronic maxillary sinusitis (long-lasting sinus problems lasting 12 weeks or more) or recurring acute maxillary sinusitis (4 or more short sinus infections per ye...

Who might be able to join this trial: - You have been diagnosed by a doctor with Chronic Rhinosinusitis (long-term inflammation or infection of the sinuses and nasal passages) - You are able to use an app on a smartphone Who may not be able to join: - You have been diagnosed with cancer in the sinus or nasal area - Yo...

Who might be able to join this trial: - You are 18 years of age or older - You have been diagnosed with chronic sinusitis (long-term sinus inflammation) with nasal polyps (small, non-cancerous growths inside the nose) - You have a reduced or lost sense of smell - Your doctor has recommended a medication called Dupiluma...

**Who might be able to join this trial:** - You are between 18 and 99 years old - You have an official diagnosis of asthma recorded by a doctor - You are receiving treatment for moderate-to-severe asthma at a higher level of care (known as GINA/DAL step 4 or 5), but are NOT currently taking steroid tablets by mouth or...

Who might be able to join this trial: - The inclusion criteria were not specified in the available information (confirm with trial site) Who may not be able to join: - Anyone who does not want to take part in the study Important: Always verify eligibility with the trial site directly before applying.

**Who might be able to join this trial:** - You are between 18 and 65 years old - You have been diagnosed with chronic sinusitis with nasal polyps (including if you also have a condition called AERD, which involves sensitivity to aspirin) - A recent swab of your sinuses showed a bacteria called *Staphylococcus aureus*...

**Who might be able to join this trial:** - You have had a chronic cough that has not responded to treatment, or a cough with no known cause, for at least one year, as diagnosed using standard medical guidelines. - A chest X-ray or CT scan of your chest taken within the past year shows no abnormality that is thought t...

**Who might be able to join this trial:** - You are between 18 and 70 years old - You have had a sinus condition (chronic rhinosinusitis) lasting more than 12 weeks, affecting both sides of your nose and sinuses, with swelling of the nasal lining and thick, discoloured mucus (confirmed by a camera examination of your...

**Who might be able to join this trial:** - You have been diagnosed by a doctor with chronic rhinosinusitis with nasal polyps (a condition where nasal polyps grow in the sinuses), with or without asthma, and you meet the requirements for using the medication Dupilumab as approved by the FDA. - You are 18 years of age o...

**Who might be able to join this trial:** - You are 18 years of age or older (male or female) - You have been diagnosed with a flare-up of chronic rhinosinusitis (CRS), meaning one or more sinus symptoms have gotten worse, such as a blocked or stuffy nose, nasal discharge, facial pain or pressure, or a reduced sense of...

**Who might be able to join this trial:** - You are 18 years or older and have nasal polyps in both nostrils - Your nasal symptoms (such as blocked nose, reduced sense of smell, mucus dripping down your throat, sneezing, and runny nose) are still significantly affecting you despite receiving standard treatment, with a...

**Who might be able to join this trial:** - You have nasal polyps in both nostrils, confirmed by a nasal camera examination (endoscopy) or a CT scan - You have had at least one surgery for nasal polyps in the last 10 years - Your nasal polyp symptoms are severe enough that surgery is being considered, based on specifi...

**Who might be able to join this trial:** - You have been diagnosed with Chronic Rhinosinusitis (long-term sinus inflammation) affecting both sides of your nose/sinuses - If you have **never had sinus surgery**, you meet at least **four** of the following conditions; if you **have had sinus surgery before**, you meet...

**Who might be able to join this trial:** - You must be willing and able to sign a consent form agreeing to take part in the study - You must be between 18 and 80 years old at the time of signing the consent form - You must be able to follow the study's rules and requirements, as judged by the study doctor - (Group 1)...

Who might be able to join this trial: - You have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation), either without nasal polyps or with small/minor nasal polyps Who may not be able to join: - You have been assessed by a doctor as having large or significant nasal polyps - You have significant a...

Who might be able to join this trial: - Adults aged 18 or older - Both men and women are eligible Who may not be able to join: - People who have chronic rhinosinusitis with nasal polyps (a condition where ongoing sinus inflammation occurs alongside growths inside the nose) - People who have allergic rhinitis (an aller...

**Who might be able to join this trial:** **For children who will be starting a highly effective CF medication (HEMT group):** - The child has been officially diagnosed with cystic fibrosis (CF) - The child is between 2 and 8 years old at their first study visit - The child has a specific CF gene type that qualifies t...

**Who might be able to join this trial:** - You have been diagnosed by a doctor with chronic rhinosinusitis (long-term sinus inflammation) with nasal polyps in both nostrils. - You have either had steroid tablets/injections in the last 2 years (or cannot take them due to a medical reason), had surgery for nasal polyps...

Who might be able to join this trial: - You must be between 18 and 99 years old - You must be willing to take part in the study - You must have chronic rhinosinusitis (a long-term sinus condition) as defined by established medical guidelines (confirm with trial site) - You may qualify for Group 1 if you have chronic si...

**Who might be able to join this trial:** - People who have already been enrolled in the related TQH2722 clinical study (study number TQH2722-II-02) for chronic sinusitis with or without nasal polyps, and who either completed that study as planned, or left early for reasons unrelated to a drug side effect — and where...

**Who might be able to join this trial:** - You are 18 years old or older and your doctor has recommended a biologic treatment (a type of medicine made from living cells) for a condition called chronic rhinosinusitis with nasal polyps (long-term blocked sinuses with growths inside the nose) - You may also be included i...

Who might be able to join this trial: - You are 18 years of age or older - You are scheduled to have your first sinus surgery (a procedure using a small camera to treat blocked sinuses) for a long-term sinus condition affecting the cheek sinuses, without nasal polyps - You have already tried non-surgical treatments (su...

Who might be able to join this trial: - You must be at least 18 years old when you sign the consent form - You must be able to understand and agree to take part in the study by signing a consent form - You must have a condition called chronic rhinosinusitis with nasal polyps (a long-term sinus condition where growths d...

Who might be able to join this trial: - You are 19 years old or older - You are scheduled to have minor sinus surgery or a coblation procedure (a type of procedure that uses radiofrequency energy to remove or shrink tissue) Who may not be able to join: - You have cystic fibrosis - You have a condition affecting your b...

Who might be able to join this trial: - You have had at least two of these symptoms for 12 weeks or more: blocked nose, runny nose, loss of smell, or pain/pressure in the face - A camera examination of your nose has shown polyps (small growths) on both sides of your nasal passages - A smell test shows your sense of sme...

**Who might be able to join this trial:** - You are over 18 years old - You have been diagnosed with chronic sinusitis with nasal polyps, confirmed using an international standard set of diagnostic criteria - You have nasal polyps visible in both nostrils when examined with a small camera (endoscope) - Your nasal poly...

**Who might be able to join this trial:** - People aged 12 to 17 years (inclusive) at the time of the first screening visit. - Female participants who are sexually active must be using an effective form of contraception (such as oral contraceptives, a patch, an IUD, or a double-barrier method), be surgically unable to...

Who might be able to join this trial: - You have a well-documented history of chronic rhinosinusitis with nasal polyps (a long-term sinus condition involving growths inside the nose) - You have had a smell test (called a BSIT) that showed an abnormal result for your age and sex - You have noticed a moderate to severe l...

**Who might be able to join this trial:** - You are between 20 and 60 years old - You are any gender - You have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation) by an ear, nose, and throat (ENT) specialist - You have had two or more of the following main symptoms for at least 12 weeks: pain or...

Who might be able to join this trial: - You must be able to understand and agree to take part in the study by giving your consent. - You must have been diagnosed with a long-term sinus condition (chronic rhinosinusitis), which may or may not include nasal polyps (small growths inside the nose). - You must not have had...

**Who might be able to join this trial:** - You have mild to moderate nasal allergy symptoms, with a symptom score of 9 or below on a standard scale - You are between 20 and 40 years old - Both men and women can apply - You have had a positive allergy test (either a skin prick test or a blood allergy test) in the last...

Who might be able to join this trial: - You are 18 years of age or older - You have been diagnosed with Cystic Fibrosis and are currently taking a highly effective modulator therapy (a specific type of Cystic Fibrosis medication — confirm with trial site if unsure) - You have a history of chronic sinusitis (long-term i...

**Who might be able to join this trial:** - People who have given written consent before the trial begins, showing they understand its goals, procedures, and possible side effects. - People aged 18 to 75 years (inclusive) at the time of signing consent, of any gender. - People who have been diagnosed with chronic sinu...

**Who might be able to join this trial:** - You are between 18 and 65 years old (male or female) - You have been diagnosed with chronic sinusitis with nasal polyps, confirmed by a camera examination of the nose, CT scan, or MRI, following current international guidelines - Your blood clotting tests (including clotting...

**Who might be able to join this trial:** - You weigh at least 40 kg (about 88 pounds) - You have been diagnosed with chronic rhinosinusitis with nasal polyps (a long-term sinus condition where growths develop inside the nose) - You have nasal polyps in both nostrils, with scores meeting a minimum level of severity as...

**Who might be able to join this trial:** - People aged between 18 and 75 years (inclusive), of any sex - People with a Body Mass Index (BMI) of at least 18.5 (BMI is a measure of body weight relative to height) - People who have been diagnosed with chronic rhinosinusitis (long-term inflammation of the sinuses and nas...

**Who might be able to join this trial:** **If you are a patient with sinus problems:** - You have at least 2 nasal symptoms, and one of them must be either a blocked nose or discoloured nasal discharge. - Your sinusitis has been confirmed by a nasal camera examination (endoscopy) or a CT scan. - Your sinus symptoms h...

Who might be able to join this trial: - You must be 18 years of age or older. - You must currently be receiving treatment with either dupilumab (300 mg) or mepolizumab (100 mg) every four weeks (these are injectable medications used to treat certain conditions including nasal polyps). - You must have been receiving thi...

**Who might be able to join this trial:** - You are between 18 and 65 years old - You have been diagnosed with chronic rhinosinusitis with nasal polyps (a condition causing blocked sinuses and growths inside the nose), confirmed using recognised medical guidelines - A blood test has shown that you have a higher-than-no...

**Who might be able to join this trial:** *Part 1 (Healthy Volunteers):* - You are a man or woman between 18 and 55 years old (inclusive) - You weigh at least 50 kg (if male) or at least 45 kg (if female), and your body mass index (a measure of body weight relative to height) is between 18.5 and 28.0 - You have no sig...

**Who might be able to join this trial:** - You are within the age range and have a health condition that fits the purpose of this trial (confirm with trial site) - Your doctor believes you would benefit from nasal rinsing/washing as part of normal care - You have at least two nasal symptoms that are moderate or worse...

**Who might be able to join this trial:** - You are 18 years of age or older - You have chronic rhinosinusitis with nasal polyps (a long-term sinus condition where growths form inside the nose) and your polyps are present on both sides of the nose - You have previously had sinus surgery (with only rare exceptions) - W...

**Who might be able to join this trial:** - You are 18 years old or older - You have been officially diagnosed with chronic rhinosinusitis (a long-term sinus condition) according to recognized medical guidelines - A CT scan taken within the last 6 months shows sinus disease affecting both sides of a specific sinus are...

Who might be able to join this trial: - Adults aged 18 or older who are having an ear, nose, or throat procedure done while awake at an outpatient clinic - People who are able to understand and agree to take part in the study by giving their consent Who may not be able to join: - People who have an allergy or sensitiv...

Who might be able to join this trial: - You have chronic rhinosinusitis (long-term sinus inflammation) that did not get better with medical treatment - You are having a first-time surgical procedure on both sides of your sinuses using a technique called functional endoscopic sinus surgery Who may not be able to join:...

Who might be able to join this trial: - You are 18 years old or older at the time of signing the consent form - You have been diagnosed with chronic sinusitis with nasal polyps for at least 1 year before starting tezepelumab treatment - Your medical records from at least 1 year before starting tezepelumab are available...

**Who might be able to join this trial:** - You are between 18 and 55 years old (for healthy volunteers) or between 18 and 75 years old (for patients), and weigh no more than 120 kg - Your Body Mass Index (BMI — a measure based on height and weight) is between 18 and 30 - If you are a woman who could become pregnant,...

Who might be able to join this trial: - You must be 16 years of age or older at the time of signing the consent form - You must have been officially diagnosed with chronic sinusitis with nasal polyps (growths inside the nose) - You must have a procedure to remove nasal polyps done during the initial screening period of...

Who might be able to join this trial: **Part A (before sinus surgery)** - Adults between 18 and 65 years old. - People who have been diagnosed with chronic sinusitis with nasal polyps (a long-term sinus condition where growths form inside the nose). - People whose nasal polyp tissue has been tested and confirmed to c...

Who might be able to join this trial: - People who are 18 years of age or older at the time of signing the consent form - People who have been diagnosed by a doctor with chronic rhinosinusitis with nasal polyps (a long-term sinus condition with growths in the nose) for at least 12 months before the first visit - People...

**Who might be able to join this trial:** - You (or a legal representative on your behalf) are willing and able to give consent to participate, following local rules - You have been treated with, or are planned to be treated with, a specific Medtronic medical device used in this study - You sign up for the study withi...

Who might be able to join this trial: - You must be under 18 years old - You must be attending a nose and sinus specialist clinic with a condition called chronic rhinosinusitis (long-term inflammation of the sinuses) along with nasal polyps (small, non-cancerous growths inside the nose) - You must have a reduced or los...

**Who might be able to join this trial:** - Adults between 18 and 60 years of age. - People who are scheduled to have one of the following sinus procedures: functional endoscopic sinus surgery, endoscopic turbinoplasty, or endoscopic septoplasty. - People who have been diagnosed with chronic sinusitis and/or nasal poly...

Who might be able to join this trial: - You have been diagnosed by a doctor with chronic rhinosinusitis (long-term inflammation or infection of the sinuses) - A surgeon has determined that you need endoscopic sinus surgery (a procedure to look inside and treat the sinuses using a small camera) Who may not be able to j...

Who might be able to join this trial: - You have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation) with nasal polyps, and your doctor has recommended sinus surgery as part of your treatment Who may not be able to join: - You have cystic fibrosis - You have a condition where taking aspirin makes...

**Who might be able to join this trial:** - You are being seen or treated at the Massachusetts Eye and Ear Sinus Center - You are between 18 and 80 years old - You have been diagnosed with chronic rhinosinusitis (long-term sinus inflammation) with nasal polyps, confirmed using recognised medical guidelines (EPOS 2012)...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with chronic sinusitis (long-term sinus inflammation) with nasal polyps, confirmed using standard medical guidelines - You are scheduled for sinus surgery on both sides of your nose, and a CT scan has shown disease in...

**Who might be able to join this trial:** - You have been diagnosed with chronic sinusitis (long-term inflammation of the sinuses), with or without nasal polyps, or a related condition called allergic fungal rhinosinusitis - Your doctor has recommended you have sinus surgery on both sides of your nose (a procedure call...