Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are able to understand and are willing to sign a consent form
• People aged 18 or older
• People who have a confirmed advanced solid tumour that has stopped responding to standard treatments, has no standard treatment available, or who have a type of blood cancer called non-Hodgkin lymphoma that has come back or stopped responding after at least 2 previous treatments
• People with an advanced solid tumour who have at least one tumour that can be measured using standard imaging criteria
• People with non-Hodgkin lymphoma whose cancer can be measured or assessed using standard lymphoma response criteria
• People with a general health/activity level rating of 0, 1, or 2 on a standard medical scale (meaning able to carry out most daily activities, with or without some limitations) (confirm with trial site)
• People who are able to provide a tissue sample from their tumour
• People with a life expectancy of at least 12 weeks

Who may not be able to join:

• People with a known history of severe allergic reaction to any ingredient in the trial drug HCB101
• People with active or untreated cancer that has spread to the brain or the lining around the brain
• People who have had major surgery, intensive radiotherapy, palliative radiotherapy, or a radioactive drug treatment that was not completed at least 2 weeks before the trial would start
• People with a significant heart or blood vessel condition
• People still experiencing side effects from previous cancer treatments that have not returned to a mild or baseline level (with the exception of hair loss and anaemia)
• People with a known inherited or acquired bleeding disorder
• People who have had a red blood cell transfusion within 4 weeks before screening
• People who have been diagnosed with a condition causing the body to destroy its own red blood cells (haemolytic anaemia or Evans Syndrome) in the past 3 months
• People currently receiving any other systemic cancer treatment, whether experimental or approved
• People currently taking a blood-thinning medication called a vitamin K antagonist (such as warfarin); certain other blood thinners may be considered on a case-by-case basis (confirm with trial site)
• People who have used herbal medicines within 14 days before the trial would start
• People who have previously received any treatment that targets the CD47 or SIRPα pathway (confirm with trial site)
• People who have had another cancer requiring treatment within the past 2 years
• People who have participated in another clinical trial using an experimental treatment within the past 14 days
• People who have used an experimental medical device within the past 28 days
• People who test positive for hepatitis B, active hepatitis C, HIV, or have known active or latent tuberculosis
• People with a known history of alcohol or drug misuse

Important: Always verify eligibility with the trial site directly before applying.