Phase 1 Pancreatitis Trial, Recruiting NCT05925036 Sponsor: VA Office of Research and Development Condition: Pancreatitis
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Phase 1 Pancreatitis Trial, Recruiting

NCT05925036
Recruiting Phase 1

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are between 18 and 75 years old (any gender)
  • You have been formally diagnosed with chronic pancreatitis based on specific medical criteria, such as calcium deposits in the pancreas, significant damage to the pancreatic ducts, clear signs that your pancreas is not digesting food properly (which improves with enzyme supplements), or results from a tissue sample showing typical signs of chronic pancreatitis (confirm with trial site)
  • You have had ongoing pain from chronic pancreatitis for more than 6 months, whether the pain is constant or comes and goes
  • Your pain score on a specific measurement scale is above 30 (confirm with trial site)
  • You have been on a stable dose of opioid pain medication for the past 30 days

Who may not be able to join:

  • You have had a flare-up of acute (sudden) pancreatitis in the last 30 days
  • You have another chronic pain condition (besides pancreatitis) that requires you to take opioid pain medication every day
  • Your blood test results show certain abnormal levels, including low red blood cells, reduced kidney function, elevated liver enzymes, high bilirubin (unless you have a specific inherited condition called Gilbert syndrome), low platelets, or poorly controlled blood sugar (confirm with trial site)
  • You have a heart failure condition that affects your daily activity even slightly (confirm with trial site)
  • You have a history of cancer, except for certain skin cancers or cancers that were fully removed by surgery and have not returned
  • You currently have an active infection being treated with antibiotics, or you have Hepatitis B, Hepatitis C, or HIV
  • You have a known severe allergic reaction (anaphylaxis) to contrast dye used in certain scans
  • You have had a problem with alcohol abuse or illegal drug use in the past six months
  • You have taken part in another clinical trial involving an experimental drug or device within the past 30 days, or you expect to do so during this study
  • You are planning to have a procedure or surgery on your pancreas within the next 6 months
  • You currently have an infected fluid collection or area of dead tissue around your pancreas
  • You are pregnant, breastfeeding, or are of childbearing potential and are not willing to use adequate contraception during the study — this applies to both female participants and male participants whose partners could become pregnant
  • You are unwilling or unable to follow the study's plan and attend required assessments

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
Phase 1: approximately ~10% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Hongjun N Wang, PhD, Ralph H. Johnson VA Medical Center, Charleston, SC

Phone: (843) 792-2813

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 1
Registry
ClinicalTrials.gov
Start date
1 January 2024
Est. completion
31 December 2026

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Change in Izbicki pain score (M6 vs. Baseline)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov