Phase 3 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with Follicular Lymphoma grade 1 to 3A, confirmed by a tissue sample (biopsy)
• Your lymphoma is at an early stage (Stage IA, IIA, or IE) and is not large (less than 7 cm), and fits within a single radiation treatment area
• If you had a PET scan before surgery, you do not need to repeat it afterward to be eligible
• You have not received any previous treatment for this lymphoma, except for steroids
• Your lymphoma risk score (called FLIPI) falls within a low range (confirm with trial site)
• You are 18 years of age or older
• Your bone marrow biopsy shows no lymphoma involvement
• You are willing to have blood and bone marrow samples tested for specific genetic markers related to this lymphoma
• Your lymph node biopsy can be reviewed centrally and tested for a specific genetic change called t(14;18)
• You are generally well enough to carry out daily activities (your performance score is 2 or below on a standard medical scale)
• You have at least one affected lymph node measuring 2 cm or more before your biopsy
• Your kidneys are working well enough (confirm specific level with trial site)
• Your liver is functioning within acceptable levels (confirm specific levels with trial site)
• You are willing and able to sign an informed consent form before the study begins
• You are able to attend all required study visits and follow the study schedule
• Your life expectancy is at least 3 months
• Women must either be past menopause (no period for at least 12 months), have had surgery to prevent pregnancy, or be using a highly effective form of contraception throughout the study and for at least 18 months after treatment ends
• Women who could become pregnant must have a negative pregnancy test before starting the study
• Men with female partners who could become pregnant must use a condom plus an additional contraceptive method during treatment and for at least 3 months after the last dose, and must not donate sperm during this time
• Men who have had a vasectomy must still agree to use effective barrier contraception or practise full abstinence during the study and for 3 months after the last dose

Who may not be able to join:

• You have been diagnosed with Follicular Lymphoma grade 3B
• Your lymphoma is at a more advanced stage (above Stage II), you have "B symptoms" (such as night sweats, fever, or unexplained weight loss), or your tumour is larger than 7 cm
• You have Stage II lymphoma with affected areas that are too spread out to be covered by a single radiation field
• Your lymphoma affects only the skin (primary cutaneous follicular lymphoma)
• You are known to be HIV positive
• You have active hepatitis C infection (a specific blood test will be used to confirm this)
• You have active hepatitis B infection based on blood test results (some people with past exposure but no active infection may still be eligible — confirm with trial site)
• Your lymphoma has spread to the brain or spinal cord
• You have a serious history of neurological, psychiatric, hormonal, immune system, or liver disease that could affect your ability to participate safely
• You have had another cancer within the past 3 years, unless it was certain early-stage or skin cancers that were fully treated and removed
• You have an active, uncontrolled infection (viral, bacterial, or fungal) or require ongoing treatment for hepatitis B or C
• You are currently pregnant or breastfeeding
• You are already taking part in another clinical trial

Important: Always verify eligibility with the trial site directly before applying.