Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with primary central nervous system lymphoma (a type of lymphoma affecting the brain or spinal cord), confirmed by a pathology test using 2016 WHO standards, and who have already received at least one round of chemotherapy but whose disease has come back or continued to grow.
• People aged 18 to 75 years old.
• People whose general physical condition falls within an accepted range on a standard medical scoring scale (ECOG performance score of 0 to 4) (confirm with trial site).
• People whose doctors expect them to live for more than 3 months.
• People who have had a full-body PET/CT scan and a head MRI within 28 days before joining the trial, showing at least one measurable area of disease, OR who have abnormal results from a spinal fluid test, OR who have confirmed disease in the retina or the gel-like fluid inside the eye.
• People whose liver, kidney, heart, blood clotting, and thyroid function all meet certain minimum health thresholds as measured by blood tests (confirm with trial site for specific values).
• Women who could become pregnant must use contraception or have a negative pregnancy test before joining, and must continue using contraception during the trial and for 90 days after the last dose.
• Men must use contraception during the trial and for 90 days after the last dose, or must have had a surgical sterilisation procedure.
• People who are willing to take part, sign a consent form, follow the study requirements, and attend follow-up appointments.

Who may not be able to join:

• Women who are pregnant or breastfeeding.
• People whose lymphoma has spread to parts of the body outside the central nervous system (brain and spinal cord).
• People with poor bone marrow function, specifically those with very low levels of certain blood cells (neutrophils, platelets, or haemoglobin) below set thresholds (confirm with trial site for exact values).
• People who have been diagnosed with another cancer (other than lymphoma), unless they were successfully treated more than 5 years ago with no known active disease, or unless they had certain skin conditions (basal cell carcinoma or cervical pre-cancer) that were fully treated with no remaining signs of disease.
• People who have a known allergy to any ingredient in the study drug.
• People who have previously received an organ transplant or stem cell transplant from another person.
• People who may need to receive other cancer treatments during the study period.
• People who have HIV, active hepatitis, or other serious infections that are not under control.
• People with a known history of significant neurological or psychiatric conditions.
• People whose drug use, or medical, psychological, or social circumstances might interfere with the study or make it difficult to assess the results.
• People considered unsuitable for the trial by the medical team running the study.

Important: Always verify eligibility with the trial site directly before applying.