Pulmonary Hypertension Trial, Recruiting NCT05935605 Sponsor: Mayo Clinic Condition: Pulmonary Hypertension
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Pulmonary Hypertension Trial, Recruiting

NCT05935605
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have been referred to a hospital for a procedure called a right heart catheterization (a test that measures pressures inside your heart) for any reason.
  • You have been diagnosed with heart failure where the heart muscle still pumps normally (sometimes called HFpEF), with symptoms like breathlessness or tiredness, AND at least one of the following: a past hospital stay for worsening heart failure treated with IV water tablets; pressure measurements from a heart test confirming the condition; a blood test result above a certain level; or a score from a standard checklist used by doctors reaching a certain threshold (confirm with trial site).
  • You have been diagnosed with heart failure where the heart muscle is weakened and does not pump well (sometimes called HFrEF), with symptoms like breathlessness or tiredness.
  • You have significant disease of your aortic or mitral heart valve (leaking and/or narrowing) along with symptoms like breathlessness or tiredness.

Who may not be able to join:

  • You are unable or unwilling to have a heart ultrasound scan (echocardiogram), or the scan would not produce good enough images for the study.
  • You have a specific type of high blood pressure in the lungs caused by the lung blood vessels themselves (including cases linked to congenital heart disease).
  • You have high blood pressure in the lungs caused by low oxygen levels or lung disease.
  • You have high blood pressure in the lungs caused by blood clots in the lung blood vessels.
  • You have high blood pressure in the lungs due to other miscellaneous causes.
  • You have significant lung disease, low oxygen levels in your blood, or a lung infection.
  • You have a condition where an abnormal protein or other substance has built up in your heart muscle (confirm with trial site).
  • You have acute (sudden, active) inflammation of the heart muscle.
  • You have had a heart attack or a procedure to open blocked heart arteries within the past 90 days.
  • You are currently taking medications specifically prescribed for pulmonary hypertension (high blood pressure in the lungs).
  • You have a condition where the sac surrounding the heart has become stiff and is squeezing the heart.
  • You have heart failure caused by the heart having to pump an unusually large amount of blood around the body.
  • You were admitted to hospital for heart failure within the last 30 days.
  • You have severe narrowing of your aortic or mitral heart valve, based on specific measurement thresholds (confirm with trial site).
  • You are unable or unwilling to exercise as part of the study.
  • Your heart ultrasound scan does not produce clear enough images.
  • You are unable or unwilling to hold your breath when asked during the study.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Barry Borlaug, MD, Mayo Clinic

Phone: (507) 255-2200

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Sponsor
Registry
ClinicalTrials.gov
Start date
20 July 2023
Est. completion
1 May 2028

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Peak Exercise Cardiac Output; Peak Exercise Oxygen Consumption (VO2)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov