Prostate Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with prostate cancer (a type called adenocarcinoma), confirmed by a tissue biopsy, across a range of grades from low to high
• People who are over 18 years of age
• People who have signed a consent form agreeing to take part in the trial
• People whose lymph nodes have been confirmed as cancer-free by imaging scans (such as a PSMA PET/CT and/or pelvic MRI) within the past 3 months, where guidelines recommend this check
• People whose cancer has been confirmed as not having spread to distant parts of the body, based on appropriate scans within the past 3 months, where guidelines recommend this check
• People with acceptable bladder flow test results — specifically, a peak urine flow ideally at or above 15 ml per second and a low amount of urine left in the bladder after urinating (50 ml or less); people with slightly lower flow rates may still be considered if a short course of hormone therapy improves results to at least 12 ml per second
• People with a general health status rated as reasonably functional (confirm with trial site for exact rating)
• People who have not previously had radiotherapy to the pelvis
• People who are able to complete quality-of-life questionnaires about urinary, sexual, and general health (confirm with trial site for specific forms required)

Who may not be able to join:

• People with serious conditions affecting other major body systems
• People with psychological or other conditions that would prevent them from being able to sign a consent form
• People who have had another invasive cancer in the past, unless it was a non-melanoma skin cancer, or unless they have been free of any cancer for at least 3 years (certain early-stage cancers such as carcinoma in situ may still be considered — confirm with trial site)
• People whose cancer has spread to the lymph nodes
• People whose cancer has spread to distant parts of the body
• People who score more than 20 points on a urinary symptom questionnaire (called the IPSS)
• People whose bladder flow test shows a maximum flow rate at or below 11 ml per second and/or more than 100 ml of urine remaining in the bladder after urinating
• People with ongoing inflammatory conditions of the urinary or digestive system, such as ulcerative colitis or Crohn's disease
• People with an overactive bladder
• People for whom small marker implants (called fiducials) cannot be placed in the prostate
• People who are unable or unwilling to have a bladder catheter inserted for planning scans
• People who are unable to have an MRI scan for treatment planning
• People for whom hormone therapy would not be medically appropriate, if their cancer risk level requires it
• People whose cancer or anatomy means that safe radiation dose limits cannot be met within the treatment plan

Important: Always verify eligibility with the trial site directly before applying.