Phase 2 COPD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged between 18 and 55 years old
• People who have documented brain or nervous system damage caused by a closed head injury (a head injury that did not break the skull), where current standard treatments are unlikely to help further
• People whose level of recovery falls within a specific range on a medical scale called the Glasgow Outcome Scale-Extended, meaning they have some ongoing difficulties but are not in the most severely affected category (confirm with trial site)
• People whose injury or diagnosis occurred more than 6 months ago but no more than 20 years ago
• People who are able to give consent themselves, or who have a legally authorised representative who can give consent on their behalf
• People who are able to communicate verbally in English or Spanish

Who may not be able to join:

• People with a known intellectual disability, or uncontrolled mental health conditions that could affect the ability to measure changes in thinking or behaviour
• People who have had a recent infection that has been treated
• People with kidney disease or reduced kidney function, based on a blood test result
• People with liver disease or reduced liver function, based on blood test results
• People with a history of cancer
• People with a weakened immune system, based on a blood test result
• People who test positive for HIV, Hepatitis B, Hepatitis C, or Syphilis
• People with alcohol or chemical dependency that, in the opinion of the lead researcher, would prevent safe participation
• People with acute or ongoing lung disease that requires significant medication or oxygen support
• People with bleeding disorders, including a specific immune-related blood clotting condition called heparin-induced thrombocytopenia
• People with a known sensitivity or allergy to heparin, Lovenox, or pork products
• People who have a mechanical prosthetic heart valve
• People who have previously received a stem cell treatment, gene therapy, or cellular therapy
• People whose brain scan (CT or MRI) shows no abnormalities
• People with a history of spinal cord injury
• People diagnosed with a genetic or metabolic disorder linked to their neurological condition
• People with other medical conditions that, in the opinion of the researcher, could increase the risks of taking part
• Women of childbearing potential who test positive for pregnancy at the screening visit, or anyone (male or female) who is unwilling to use an acceptable form of birth control during the trial
• People who are currently taking part in another clinical trial involving a drug or medical device
• People who are unable or unwilling to undergo the required brain scans (PET scan and a specific type of MRI) or to cooperate with the assessments
• People who have metal implants in their body — including baclofen pumps — that would make the specialised MRI scan unsafe or impossible
• People who are unwilling or unable to return for the required follow-up visits

Important: Always verify eligibility with the trial site directly before applying.