Phase 3 Vasculitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with a condition called EGPA (a type of inflammatory disease affecting blood vessels) for at least 6 months
• Your EGPA has come back after treatment or has not responded well to treatment
• You have been taking oral prednisone (a steroid) at a steady dose of at least 7.5 mg per day but no more than 50 mg per day for at least 4 weeks before joining the trial
• If you are taking other immune-suppressing medicines (not including cyclophosphamide), your dose must have been stable for at least 4 weeks before joining and must stay stable during the study

Who may not be able to join:

• You have another disease that causes high levels of a type of white blood cell called eosinophils
• You have been diagnosed with a related condition called GPA (granulomatosis with polyangiitis) or MPA (microscopic polyangiitis)
• Your EGPA was life-threatening within the last 3 months
• You have had cancer at any point in the last 5 years
• You have a weakened immune system
• You have high blood pressure that is not well controlled
• You have heart or stroke-related conditions that are not well controlled
• You have had a parasitic infection in the last 6 months
• You have had an active infection requiring treatment in the last 4 weeks
• You have taken more than 50 mg per day of oral prednisone in the last 4 weeks
• You have taken a medicine called cyclophosphamide (by mouth or through a vein) in the last 4 weeks
• You have received immunoglobulin treatment (by vein or injection under the skin) in the last 12 weeks
• You have used certain biological medicines or immune-targeting treatments in the last 12 weeks, or within a specific window based on how long the drug stays in your body (confirm with trial site)
• You have received a medicine called rituximab in the last 6 months
• You have planned surgery that could affect the study results
• You have significant abnormal results on blood or other laboratory tests (confirm with trial site)
• You have a certain type of irregular heart rhythm or other heart electrical abnormality that poses a safety risk
• You have had a problem with drug, substance, or alcohol misuse in the last year
• You have taken part in another clinical trial and received an active study drug within the last 30 days, or within a specific window based on how long that drug stays in your body (confirm with trial site)
• You are currently pregnant, breastfeeding, or planning to become pregnant
• You have had a serious allergic reaction or bad response to similar biological medicines in the past, or a previous treatment targeting IL-5 did not work for you
• The trial doctor decides there are other reasons the trial may not be right for you (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.