Motor Neurone Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with ALS (also called Lou Gehrig's disease) based on the 2020 Gold Coast diagnostic guidelines
• You are 18 years of age or older
• You are able to understand and agree to the study procedures and treatments on your own
• You are allowed to be currently taking or planning to start standard ALS medications, such as riluzole (by mouth) or edaravone (by mouth or through an IV)
• You are able to lie flat on your back without a breathing support machine (BiPAP) and without breathing discomfort for at least one hour
• You do not have any of the listed reasons that would make the brain stimulation procedure (TMS) unsafe for you (see exclusion list below for details)
• If you take certain medications that can affect the brain stimulation measurements (such as sleep aids, muscle relaxants, or antidepressants), you have been on a stable dose for at least 30 days before your first visit, or you have stopped taking them for at least 2 weeks beforehand

Who may not be able to join:

• You have been diagnosed with dementia
• You are pregnant or think you might be pregnant (if applicable)
• You have a known allergy to the gel used with standard brain monitoring electrode pads
• You are unable to tolerate the brain stimulation (TMS) procedure
• You have not had a brain MRI done before joining, or you are unable to have an MRI done because of breathing difficulties when lying flat
• Your body size makes it uncomfortable to fit inside the MRI scanner
• You have difficulty lying still for up to one hour, or you experience significant claustrophobia (fear of enclosed spaces)
• You have metal implants in your body that are not safe for use in an MRI scanner
• You have previously received repetitive TMS (rTMS) treatment for any reason, as this could affect the study results
• You have raised pressure in your skull, a growth in your brain, a history of seizures (except those caused by a specific medical treatment called ECT, or a fever-related seizure in early childhood), or significant head injury with evidence of brain blood vessel damage on a scan
• You have a metal implant inside or near your head (not including dental work in your mouth) that cannot be safely removed
• You have significantly abnormal blood test results, in the opinion of the study doctors
• You are currently taking more than a certain amount of sedative medication (equivalent to more than 2 mg of lorazepam per day) or any anti-seizure medication, as these may reduce how well the treatment works
• You have any other health condition that the study doctor believes would put you at increased risk or prevent you from completing the study

Important: Always verify eligibility with the trial site directly before applying.