Phase 3 Ankylosing Spondylitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 65 years old (inclusive), of any gender
• You have been diagnosed with axial osteoarthritis (a type of spinal joint disease) based on 2009 ASAS guidelines, and your condition is currently active, shown by specific scores on two pain and disease activity rating scales
• Your condition matches a Traditional Chinese Medicine pattern described as "kidney yang deficiency and blood stasis obstruction syndrome" (confirm with trial site)
• A CT scan shows your sacroiliac joint (where your spine meets your pelvis) is affected at a mild to moderate level (grades I–II)
• You have tested positive for a genetic marker called HLA-B27
• Your blood tests show raised inflammation levels (CRP and/or ESR)
• You are willing to take part voluntarily and sign a consent form

Who may not be able to join:

• You have taken anti-inflammatory painkillers (NSAIDs) in the 2 weeks before joining
• You have taken certain Chinese herbal medicines, disease-modifying drugs (such as methotrexate or sulfasalazine), opioid painkillers, JAK inhibitor drugs, or steroid tablets in the 4 weeks before joining
• You have had surgery on your spine or joints in the 8 weeks before joining
• You have received biologic medicines used for spinal arthritis in the 12 weeks before joining
• You have had steroid injections into a joint, the spine, or the area around the spine in the 6 months before joining
• Your CT scan shows the sacroiliac joint space has completely disappeared or your spine has become fully rigid
• You have been diagnosed with another immune system or rheumatic disease, such as active ulcerative colitis, psoriasis, or uveitis
• You are planning to try to have a child within the next six months
• You are currently pregnant or breastfeeding
• You have a known or suspected problem with misuse of drugs, substances, or alcohol
• You have taken part in another clinical trial in the past 3 months or are currently in one
• You have serious heart, liver, kidney, brain, or mental health conditions that may affect your ability to give consent or to report side effects
• Your liver or kidney function blood tests are outside the normal range
• The trial researchers consider you unsuitable for any other reason (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.