Phase 1 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with an advanced or spreading solid tumor (confirmed by a tissue or cell sample), and your tumor tests positive for a specific protein called CD70 (confirmed by lab testing)
• You have already tried certain standard treatments (such as targeted therapy or anti-vascular drugs) and they have not worked, are no longer available, have stopped working, or you were unable to tolerate them
• You have at least one tumor that can be measured on a scan, meeting specific size requirements (confirm with trial site for exact measurements)
• Your general health and ability to carry out daily activities scores between 0 and 2 on a standard medical scale (meaning you are able to care for yourself, even if you cannot do heavy physical work)
• Your doctors expect you to live for at least 12 weeks
• You do not have a serious mental health condition
• Your blood counts, heart, kidneys, liver, and oxygen levels are all within acceptable ranges as measured by standard tests (confirm with trial site for exact values)
• You are able to have blood or immune cells collected from your body without any medical reasons preventing this
• You agree to use reliable contraception (not rhythm-based methods) for 1 year after receiving the treatment
• You (or your legal guardian) are willing to sign a consent form agreeing to take part in the trial

Who may not be able to join:

• You have previously received any treatment that targets the CD70 protein
• You currently have active or symptomatic cancer that has spread to the brain or the lining of the brain (those who had brain metastases that were treated may still be eligible if scans show no growth for at least 4 weeks after treatment ended — confirm with trial site)
• You have recently taken part in another clinical study using an unapproved drug within 3 months, or a marketed drug within 5 half-lives, before the scheduled cell infusion
• You received chemotherapy, targeted therapy, or similar cancer treatments within 2 weeks (or 5 half-lives, whichever is shorter) before the cell collection procedure
• You have been taking steroid medicines (such as prednisone) at doses above 10mg per day within 2 weeks before cell collection (low-dose inhaled or topical steroids may be allowed — confirm with trial site)
• You received a live vaccine within 4 weeks before entering the study
• You have an active infection or an infection that cannot be controlled and requires treatment within 1 week before screening
• You have been diagnosed with another cancer in the past 3 years, unless it was fully treated with no signs of return for at least 3 years, or it was a type of non-melanoma skin cancer with no current signs of disease
• You have significant heart problems, such as severe heart failure, a heart attack or bypass surgery within the past 6 months, serious irregular heartbeat, unexplained fainting (unless due to low blood pressure or dehydration), or a history of serious non-ischemic heart muscle disease
• You have an active or uncontrolled autoimmune disease (such as Crohn's disease, rheumatoid arthritis, or lupus)
• You have certain active viral infections, including active Hepatitis B, Hepatitis C, HIV, syphilis, or cytomegalovirus (CMV), based on specific blood test results (confirm with trial site for exact criteria)
• You have had a serious blood clot event (such as a pulmonary embolism) and still need blood-thinning medication, or you have ongoing complications from a clot, or you had severe bleeding lasting more than 30 days (confirm with trial site for full details)
• You have poorly controlled high blood pressure (generally defined as 150/90 mmHg or higher, even after treatment)
• You are currently pregnant or breastfeeding, or you or your partner plan to have a child within 1 year of receiving the treatment
• The trial doctors believe there is another reason you should not take part (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.