Phase 2 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with prostate cancer (adenocarcinoma type) confirmed by a tissue sample, where the cancer is at an early-to-locally advanced stage and has not spread to the lymph nodes, bones, or other organs — though a small number of lymph node findings on a specific type of scan (PSMA scan) may be allowed (confirm with trial site)
• People whose initial prostate biopsy was done within the last 3 months, is available for review by the trial's pathology team, and shows a high-grade cancer pattern meeting specific scoring thresholds (confirm with trial site for exact biopsy requirements)
• People who have already had surgery to remove the prostate (radical prostatectomy) scheduled
• People aged 18 or older
• People who are generally in good physical health and able to carry out daily activities, as measured by standard health performance scales (confirm with trial site)
• People whose blood, liver, and kidney function test results fall within acceptable ranges as defined by the trial (confirm with trial site for specific values)
• People willing to sign a consent form and allow their health information to be shared as required by the study
• People willing to use barrier contraception (such as condoms) from the first dose of the study drug until the time of their prostate surgery

Who may not be able to join:

• People whose cancer has spread to the lymph nodes (as seen on a CT scan) beyond what the trial allows, or to distant parts of the body
• People whose prostate cancer is a less common type, such as ductal, sarcomatous, lymphoma, small cell, or neuroendocrine prostate cancer
• People who have previously received radiation therapy, hormone therapy, biological therapy, or chemotherapy for prostate cancer
• People who have previously received immunotherapy or vaccine-based therapy for prostate cancer
• People who have previously used experimental treatments for prostate cancer
• People currently taking other hormone therapies or a type of medication called 5-alpha-reductase inhibitors at the same time as the study treatment
• People currently using steroid medications taken throughout the whole body (systemic corticosteroids), or who have used them within the past 4 weeks — though inhaled steroids for asthma or lung conditions, and creams or other non-systemic steroids, are generally permitted
• People with a history of, or currently having, an autoimmune disease that requires medication to suppress the immune system (such as lupus, rheumatoid arthritis, multiple sclerosis, or similar conditions)
• People who have had another cancer diagnosed within the last 3 years, with the exception of certain skin cancers and superficial bladder cancer
• People with serious uncontrolled health conditions affecting the heart, lungs, blood, mental health, or involving active infection, which could make participation unsafe
• People with a known history of HIV, or current or past hepatitis B or C — except for people who have been fully and successfully treated for hepatitis B or C, with documented proof of cure at least 6 months after completing that treatment

Important: Always verify eligibility with the trial site directly before applying.