Phase 2 Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 55 years of age or older; women must be post-menopausal or agree to use an approved form of birth control, and men must also use contraception if their partner could become pregnant
• You have been diagnosed with major memory loss or dementia thought to be caused by Alzheimer's disease (including cases where both Alzheimer's and vascular causes are involved)
• You have scored 24 or below on a standard memory and thinking test called the sMMSE
• You are showing noticeable agitation (restlessness or distress) that was confirmed at both your screening and baseline appointments
• If you are already taking memory-related medications (such as cholinesterase inhibitors or memantine), your dose has been stable for at least 3 months before joining the study
• You have a primary caregiver who can attend study visits with you, spends at least 10 hours a week with you, and is sufficiently able to communicate in English
• You are able to give your own consent to participate, or someone legally authorised to make decisions on your behalf can do so

Who may not be able to join:

• Your mental health medications (such as antidepressants or antipsychotics) have been changed too recently before screening, or you plan to change them during the study
• You have a known allergy to cannabis or cannabis products, or take medications that could interact badly with cannabinoids (confirm with trial site)
• You have significant blood vessel disease, serious cerebrovascular disease, or uncontrolled heart conditions — including uncontrolled high blood pressure, heart disease, irregular heartbeat, severe heart failure, or a stroke in the 3 months before screening
• Your liver function blood tests show results significantly above the normal range
• You have significantly reduced kidney function, as judged by the study doctor
• You are currently experiencing a major depressive episode, have a history of serious psychiatric conditions (such as schizophrenia or psychosis), or neurological conditions such as epilepsy or stroke
• You currently have a substance use disorder (not including caffeine or nicotine)
• You are experiencing significant delusions or hallucinations
• You have used marijuana or any cannabis-based products within 1 week before joining the study
• Your blood pressure readings at screening or baseline are outside the acceptable range, or you experience a significant drop in blood pressure when standing up

Important: Always verify eligibility with the trial site directly before applying.