Phase 2 Pulmonary Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Healthy volunteers may be eligible if they:

• Are over 18 years old and are being seen as an outpatient
• Are willing and able to give informed consent and follow the study schedule
• Have no diagnosed lung conditions
• Have not smoked in the past 5 years
• Have a smoking history of 5 pack-years or less (if any history at all)
• Have not regularly used inhaled products (such as inhalers or vapes) more than once a week for more than one year

People receiving a blood transfusion or phlebotomy (blood removal) may be eligible if they:

• Are over 18 years old (inpatient or outpatient, any gender)
• Are willing and able to give informed consent and follow the study schedule
• Are scheduled to receive a red blood cell transfusion for anemia, OR are scheduled for therapeutic phlebotomy (a procedure where blood is removed to treat a condition where the body makes too many red blood cells), OR are a healthy volunteer donating blood who also meets the healthy volunteer criteria listed above

People receiving oxygen treatment may be eligible if they:

• Are over 18 years old (inpatient or outpatient, any gender)
• Are willing and able to give informed consent and follow the study schedule
• Have been diagnosed with Interstitial Lung Disease (a group of lung conditions that cause scarring) by a lung specialist, OR have been referred to a specialist for unexplained shortness of breath, OR have been diagnosed with Chronic Thromboembolic Pulmonary Hypertension (CTEPH — a condition involving high blood pressure in the lungs caused by old blood clots) meeting specific pressure measurements confirmed by a heart procedure, are scheduled for a specific type of lung surgery, and are willing to return for optional follow-up scans 3–6 months later, OR are a healthy volunteer who meets the healthy volunteer criteria listed above

People with a pulmonary embolism (blood clot in the lungs) may be eligible if they:

• Are over 18 years old (inpatient or outpatient, any gender)
• Are willing and able to give informed consent and follow the study schedule
• Have had an acute (sudden/recent) pulmonary embolism and are 24–48 hours past hospital admission, and are willing to return after 3–6 months of blood-thinning treatment, OR have been diagnosed with CTEPH meeting specific pressure measurements confirmed by a heart procedure, are scheduled for a specific type of lung surgery, and are willing to return for optional follow-up scans 3–6 months later

Who may not be able to join:

• People for whom an MRI scan is not safe based on a standard MRI screening questionnaire
• People who are pregnant or breastfeeding
• People whose blood oxygen level is below 90% even with the maximum oxygen that can be delivered through a nasal tube
• People who have had a respiratory illness caused by a bacterial or viral infection within the past 30 days
• People with a known history of abnormal heart rhythms originating in the lower chambers of the heart
• People who have had a cardiac arrest within the past year
• People whose body size does not fit the specialised MRI vest used in the study
• People who cannot hold their breath for 10 seconds
• People who are unlikely to be able to follow instructions during the scan
• People with medical or psychological conditions that, in the opinion of the study team, could put them at undue risk or prevent them from following the study requirements

Important: Always verify eligibility with the trial site directly before applying.