Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who have been diagnosed with follicular lymphoma (a type of slow-growing blood cancer), Grade 1 to 3A, confirmed by a tissue biopsy — people with a history of this lymphoma transforming into a faster-growing type may also be considered at the doctor's discretion
• People whose follicular lymphoma has come back or stopped responding to at least 2 previous rounds of treatment
• People who are reasonably well and able to carry out daily activities (as measured by a standard medical scale called ECOG, scored 0–2)
• People whose kidneys, liver, blood, and lungs are functioning well enough to be considered suitable for CAR-T cell therapy (confirm with trial site for specific values)
• People who have at least one area of lymphoma that can be measured on a scan (CT or MRI) or physical exam, at least 1 cm in size
• People who have previously had radiation therapy, provided it has not already reached the maximum safe dose for surrounding healthy tissue
• Women who could potentially become pregnant must have a negative pregnancy test within one week before radiation treatment planning
• People who are able to understand the trial and are willing to sign a consent form

Who may not be able to join:

• People who have had another type of cancer (other than B-cell lymphoma) in the past 3 years that has required active treatment such as surgery, radiation, or systemic therapy — skin cancers that are not melanoma are generally excluded from this restriction
• Women who are currently pregnant
• Women who are breastfeeding and are not willing to stop before the chemotherapy preparation phase and for 12 months after receiving the CAR-T cell treatment
• People who urgently need additional chemotherapy or a drug called rituximab in the period between the cell collection step and the CAR-T cell infusion (steroids may still be permitted)
• People for whom additional radiation therapy would exceed the safe limits for surrounding healthy organs
• People who have had a severe, immediate allergic reaction to a group of antibiotics called aminoglycosides
• People who have an active, uncontrolled fungal, bacterial, or viral infection that requires intravenous (drip) antibiotics — some milder infections that are responding to treatment may still be permitted (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.