Phase 1 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older.
• People who have previously had their prostate removed (prostatectomy) and/or received radiation treatment to the prostate.
• People whose PSA level is rising — specifically at or above 0.2 ng/ml after prostate removal, or at least 2 points above their lowest recorded PSA level after radiation therapy only. Note: people who were not offered follow-up radiation therapy as an option (due to high PSA or other health concerns) would not be eligible.
• People who have had at least 2 PSA test results, each taken more than one week apart, both showing a rise.
• People whose PSA level is doubling in less than 9 months, based on a test taken within 60 days of agreeing to join the trial.
• People whose testosterone level is above 150 ng/dl at the time of joining, indicating normal hormone levels.
• People who previously received hormone therapy (ADT) for up to 24 months as part of their original prostate treatment, as long as that therapy finished at least 12 months before joining the trial.
• People with a general health and activity level rated as fully active or restricted only in physically strenuous activity (ECOG score of 0 or 1).
• People who are willing to take the study medications at the specified doses with meals.
• People who are willing to stop taking their current vitamin and mineral supplements and use only those provided by the study (herbal supplements may still be taken).

Who may not be able to join:

• People who currently have Chronic Lymphocytic Leukemia (CLL), a condition called Monoclonal Gammopathy of Unknown Significance (MGUS), Kidney (Renal Cell) Cancer, or any other cancer that currently requires active treatment. Slow-growing or stable skin cancers (non-melanoma) are generally allowed (confirm with trial site).
• People with active or worsening liver disease, kidney disease, HIV, Hepatitis B, Hepatitis C, or bone marrow problems.
• People who have had allergic reactions to turmeric, metformin, or chemically similar substances.
• People with a history of a condition called lactic acidosis, or health factors that increase that risk — such as reduced kidney function, use of certain medications (e.g., topiramate), heart failure, heavy alcohol use, or liver problems.
• People with any other health condition that, in the trial doctor's judgment, could make participation unsafe (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.