Phase 3 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have breast cancer that has spread locally or to other parts of the body, and it cannot be cured with current treatments
• Your tumor has tested positive for estrogen receptors (ER+) and negative for a protein called HER2 (HER2−), based on a recent or archived tissue sample
• You have had a blood test (through the trial's central lab) to check for a specific gene change called an ESR1 mutation
• Your cancer came back or grew while on, or within 12 months of finishing, a standard hormone-blocking therapy given after your original diagnosis
• You have not yet received any systemic (whole-body) treatment for your advanced or metastatic breast cancer
• Your cancer can be measured on scans, or you have disease in bones only (even if not easily measured)
• You are fairly active and able to carry out daily activities with little or no limitation (confirm with trial site)
• If you are a woman who has not yet gone through menopause, or if you are a man, you must be willing to receive and continue a specific hormone-suppressing injection throughout the trial

Who may not be able to join:

• You have already received chemotherapy, immunotherapy, or other systemic cancer treatments for your advanced or metastatic breast cancer
• You have previously been treated with certain hormone-blocking drugs called SERDs (such as fulvestrant) or similar newer estrogen-targeting therapies
• Your cancer has spread to internal organs in a way that is causing serious symptoms and could become life-threatening in the near future
• You have a currently active heart condition or a significant history of heart problems
• You have a significant history of serious liver disease

Important: Always verify eligibility with the trial site directly before applying.