Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been taking an acetylcholinesterase inhibitor (a common Alzheimer's medication) for at least 2 months before joining, and whose dose can stay the same throughout the trial.
• People aged 60 to 85 years, either male or female.
• People who have been diagnosed with mild-stage Alzheimer's Disease using recognised diagnostic guidelines (NIA-AA 2011).
• People whose Alzheimer's disease has been confirmed by a type of brain scan called an amyloid PET-CT.
• People whose score on a standard memory and thinking test (called the MMSE) falls between 21 and 26.
• People whose score on either the CDR (a dementia rating scale) is 1, or whose score on the GDS (another rating scale) is 3.
• People who are found to be physically suitable to take part, based on their medical records and a physical check-up.
• People who are not able to give consent on their own due to difficulties with decision-making, but whose legally authorised representative can give consent on their behalf, and who can attend appointments with a caregiver present.
• People who agree to take part in all visits and activities over the full 24-week trial period.
• People with normal ability to see and read text, and to hear.
• People whose first language (mother tongue) is Korean.

Who may not be able to join:

• People who have other brain or nervous system conditions that could explain their memory and thinking difficulties — such as vascular dementia, brain tumours, brain infections, Parkinson's disease, Huntington's disease, head injury, or similar conditions.
• People who have lost consciousness due to brain surgery or a concussion, or who show signs of increased pressure in the skull on neurological examination.
• People with a history of epilepsy or epileptic seizures.
• People who have had a history of drug or alcohol misuse at any point in the 5 years before screening.
• People with certain mental health conditions, including schizophrenia, schizoaffective disorder, bipolar disorder, a current major depressive episode, psychosis, panic disorder, post-traumatic stress disorder, severe anxiety, intellectual disability, or other conditions classified under DSM-V (confirm with trial site).
• People with abnormal vitamin B12, folic acid, or thyroid hormone test results that the investigating doctor believes are affecting, or are caused by, the severity of their dementia.
• People who have certain metal implants in the head, such as cochlear implants, brain stimulators, or aneurysm clips (confirm with trial site regarding exceptions).
• People who have a cardiac pacemaker.
• People who have an implanted medication pump.
• People who have intracardiac lines (tubes or devices placed inside the heart).
• People who are currently taking medications that lower the threshold for seizures (make seizures more likely).
• People with significant heart disease.
• People with severe kidney or liver disease that meaningfully affects daily life — for example, stage 4 chronic kidney disease — as judged by the investigating doctor.
• People for whom having an MRI scan would not be safe or suitable.
• People for whom having an amyloid PET-CT scan would not be safe or suitable.
• People who do not agree to receive TMS (a type of brain stimulation) treatment or to take part in the trial.
• People who have taken part in another clinical trial within the 3 months before joining this one (note: non-interventional studies such as observational studies may be acceptable — confirm with trial site).
• People who have received TMS treatment at any point in the 2 years before joining this trial.
• People with a history of a malignant tumour (cancer) within the last 5 years — though participation may be considered if more than 5 years have passed since the cancer was declared fully treated and there has been no recurrence.
• People who need to take any medications that are listed as prohibited alongside this trial's treatment (confirm specific medications with trial site).
• People who the investigating doctor considers unsuitable for any other reason.

Important: Always verify eligibility with the trial site directly before applying.