Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have given written consent to take part in the research
• Women who have gone through menopause and have been diagnosed with invasive breast cancer
• People whose cancer is at a specific stage — the tumour is a certain size, cancer has spread to nearby lymph nodes, but has not spread to distant parts of the body (clinical stage T1-3N1M0 — confirm with trial site)
• People whose cancer test results show strong hormone receptor (ER) positivity and no HER2 protein overexpression, confirmed through specific laboratory tests
• People who have not yet received any treatment for their breast cancer
• People with a healthy heart, with heart pumping function (LVEF) at 50% or above, and no significant heart disease
• People who are in good general health and able to carry out normal daily activities with little or no limitation, and fit enough to receive chemotherapy
• People whose recent blood test results (within the past week) show healthy levels of white blood cells, neutrophils, platelets, and haemoglobin
• People whose recent liver and kidney function test results (within the past week) are within an acceptable range
• People who test negative for pregnancy before joining the trial, and who are willing to use medically accepted contraception during the study if there is any chance of pregnancy
• People who are likely to follow the trial schedule and requirements consistently

Who may not be able to join:

• Women who are pregnant, breastfeeding, or who test positive for pregnancy at the start and are not willing to use effective contraception during the study
• People with a known history of severe allergic reactions to any of the trial drugs, or any clearly documented drug allergy
• People who have cancer in both breasts, or who have inflammatory breast cancer
• People whose breast cancer has already spread to distant parts of the body (stage IV) at the time of diagnosis
• People with a history of heart failure, unstable chest pain (angina), irregular heartbeat, or heart attack
• People who currently have an active lung condition, including lung inflammation or scarring of the lungs
• People who currently have a serious liver condition such as acute or severe hepatitis, or a liver disease affecting blood clotting; people with certain hepatitis B markers in their blood may need to meet an additional virus level requirement (confirm with trial site)
• People with any other serious illness or ongoing health condition that could affect safety or interfere with taking part in the study, such as an active or uncontrolled infection
• People who have or have had another type of invasive cancer that could affect how the study results are measured
• People who have previously received chemotherapy, hormone therapy, or anti-HER2 biological therapy for breast cancer (routine diagnostic biopsy is not considered treatment for this purpose)
• People who have had major surgery within the four weeks before joining, or who have significant unresolved health issues
• People whose tumour cannot be measured during the course of treatment
• People who the trial doctors consider unsuitable for any other reason

Important: Always verify eligibility with the trial site directly before applying.