Phase 3 Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 55 and 90 years old (inclusive)
• You are able to understand what the trial involves and can give your consent to participate
• You have been diagnosed with possible or probable Alzheimer's disease
• You have had a brain scan (MRI or CT) within the past 5 years to rule out other causes of your dementia, or you are willing to have one done during the screening process
• You have been living in the same home or assisted-living facility for at least 6 weeks before joining
• You have someone in your life (such as a family member or carer) who has contact with you for around 10 or more hours per week
• You have been experiencing psychotic symptoms (such as hallucinations or delusions) for at least 2 months before screening
• Your symptoms are rated at a certain level of severity on medical assessment scales at both screening and baseline (confirm with trial site)
• Your Alzheimer's-related hallucinations and delusions meet a specific severity threshold on a standard assessment tool (confirm with trial site)
• Your memory and thinking abilities fall within a certain range on a standard cognitive test (confirm with trial site)

Who may not be able to join:

• Your psychotic symptoms appear to be caused by something other than your Alzheimer's disease
• You have had a major episode of depression with psychotic features in the past 12 months
• You have a history of bipolar disorder, schizophrenia, or schizoaffective disorder
• You have serious or severe health conditions affecting organs such as the lungs, liver, kidneys, heart, or other significant medical issues that the trial doctor feels could affect your safety or the study results
• You have a history of, or are considered at high risk for, difficulty passing urine, stomach retention problems, or a specific type of eye pressure condition called narrow-angle glaucoma
• You have previously been treated with the study drug KarXT
• You have had an allergic reaction to KarXT or a medication called trospium chloride
• You have previously had significant side effects from a medication called trospium
• You have taken part in another clinical trial involving an experimental drug within the past 3 months, or have been in more than 2 clinical trials in the past 12 months
• There may be additional criteria not listed here (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.