Asthma Trial, Recruiting NCT06126692 Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Condition: Asthma
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Asthma Trial, Recruiting

NCT06126692
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

People with severe asthma:

  • You have severe asthma that requires high-dose inhaled steroids (at least 1600 micrograms of Budesonide per day) plus at least one other asthma controller medication.
  • You have had at least 2 asthma attacks in the past year, or you take steroid tablets (like Prednisolone) at least half of the time, or your asthma symptoms are poorly controlled (based on a questionnaire score above 1.5).
  • You meet your country's requirements to be considered for a special biologic asthma treatment.

People with mild or moderate asthma:

  • You have mild or moderate asthma managed with low or medium doses of inhaled steroid and reliever combination inhalers, with well-controlled symptoms (questionnaire score below 1.5), no asthma attacks in the past year, and no need for steroid tablets.
  • You have signs of a specific type of airway inflammation (confirmed through blood tests, sputum tests, or breathing tests) (confirm with trial site).
  • You are not currently a candidate for biologic (antibody-based) asthma treatments.

Healthy volunteers:

  • You have no history of asthma, breathing problems, or allergies, have normal lung function, and have had no chest or respiratory infections in the past 4 weeks.

Who may not be able to join:

People with severe asthma:

  • You have a known allergy to the study medication or any of its ingredients.
  • You have taken part in another clinical trial or received an experimental medicine within the past 3 months (or within a certain timeframe based on the medicine used).
  • You have another significant health condition that is not well controlled, or that may affect your ability to take part in the study.

People with mild or moderate asthma:

  • You are unable to read or understand written information due to language barriers.
  • You are unable to give your own consent to take part in the study.
  • Your asthma is currently poorly controlled (based on a questionnaire score above 1.5, use of steroid tablets, or an asthma attack in the past year).

Healthy volunteers:

  • You are unable to read or understand written information due to language barriers.
  • You are unable to give your own consent to take part in the study.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 2 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Registry
ClinicalTrials.gov
Start date
10 January 2022
Est. completion
1 November 2027

Where this trial is recruiting

🇩🇰 Denmark 🇳🇱 Netherlands

Primary endpoints

Change in Asthma Control Questionnaire 5 (ACQ-5) score; Change in post- broncodilator Forced Expiratory Volume after 1 second (FEV1); Absense of exacerbations; No usage of oral corticosteroids in the previous 12 months

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 2 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov