Phase 4 Stroke Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older
• People experiencing symptoms of an acute ischemic stroke (a stroke caused by a blocked blood vessel)
• People whose imaging (CTA or MRA scan) has confirmed a blockage in a specific artery supplying the front part of the brain (the intracranial carotid artery or certain segments of the middle cerebral artery)
• People who are enrolled in the trial within 24 hours of when their stroke symptoms started, or within 24 hours of when they were last known to be well
• People who were able to live mostly independently before the stroke (a pre-stroke disability score of 2 or less on a standard scale)
• People with a stroke severity score of 6 or higher at the time of enrolment, indicating at least a moderate stroke
• People whose brain scan shows that a sufficient amount of brain tissue is still potentially salvageable (an ASPECTS score of 3 or higher)
• People who have provided signed informed consent to participate

Who may not be able to join:

• Women who are pregnant or breastfeeding
• People with a known allergy to contrast dye used in medical scans, or to nitinol (a metal used in some medical devices)
• People with a known allergy to midazolam or related medicines (benzodiazepines)
• People with a known allergy to dexmedetomidine or any of its ingredients
• People who are planned to receive full general anaesthesia for their stroke procedure
• People with blood pressure that is too high or too low and cannot be controlled (systolic above 185 or below 90 mmHg, or diastolic above 110 or below 60 mmHg)
• People with certain heart rhythm problems, specifically second- or third-degree heart block, or a resting heart rate below 50 beats per minute
• People who have had major surgery or a serious injury within the past 14 days
• People with a known bleeding disorder, or blood test results showing low platelet count or abnormal clotting measures
• People with blood sugar levels that are dangerously low or very high
• People with severe kidney disease or very poor kidney function
• People currently receiving kidney dialysis (haemodialysis or peritoneal dialysis)
• People whose life expectancy is less than one year
• People experiencing severe agitation or seizures at the time of enrolment
• People showing signs of inflammation of the blood vessels in the brain (central nervous system vasculitis)
• People with a pre-existing neurological condition or mental health disorder that would make it difficult to assess the effects of the treatment
• People who are unwilling to attend a follow-up assessment at 90 days
• People already participating in another interventional clinical trial
• People whose brain scan shows any bleeding in the brain
• People whose scan shows a cerebellar stroke (stroke in the back of the brain) that is causing significant swelling or pressure
• People with an untreated or incompletely treated brain aneurysm or abnormal blood vessel formation in the brain
• People with blockages in multiple brain blood vessels, or blockages on both sides of the brain
• People with a brain tumour that is causing pressure or swelling in the brain

Important: Always verify eligibility with the trial site directly before applying.