Stroke Trial, Recruiting (NCT06148051)

Stroke Trial, Recruiting NCT06148051 Sponsor: Perminder Sachdev Condition: Stroke

Printed from Voxsanity (voxsanity.com.au) — NCT06148051 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.

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Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

Adults aged 18 years or older
People who are able to give written consent to participate (a large-print version is available for people with visual impairment, and an easy-to-read version is available for people who need extra support due to cognitive difficulties)
People who are able to travel to a testing site in person
People who are able to complete a set of required assessments, including a medical examination, a medical history questionnaire, a blood test to check genetic status, and a short neuropsychology assessment (approximately 20 minutes)
People who have a confirmed diagnosis of CADASIL through genetic testing (a specific gene change called a NOTCH3 pathogenic variant), OR
People with a suspected CADASIL diagnosis based on their medical history and brain MRI results, OR
People who are a close blood relative (such as a parent, sibling, or child) of someone who has tested positive for the NOTCH3 gene change, OR
People who are not related to any trial participant, have tested negative for the NOTCH3 gene change, and have no concerns about their memory or thinking (these participants serve as a comparison group)

Who may not be able to join:

People whose level of cognitive impairment means they are unable to give informed consent to participate

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.

Last synced 26 July 2026

This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Perminder S Sachdev, MBBS, MD, PhD, FRANZCP, FAAHMS, University of New South Wales

Phone: 9348 1658

Australian sites

John Hunter Hospital, Newcastle, New South Wales
4055 0650

Prince of Wales Hospital, Sydney, New South Wales
93481658

University of New South Wales, Sydney, New South Wales
93481658

Royal Brisbane and Women's Hospital, Brisbane, Queensland
3646 8111

Royal Melbourne Hospital, Melbourne, Victoria
9342 7000

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Voxsanity

Clinical trials and treatments, explained plainly · voxsanity.com.au

Date:

To: My Doctor

Re: Clinical trial enquiry

I am writing to enquire about the following clinical trial which may be relevant to my care:

Trial: NCT06148051

Sponsor: Perminder Sachdev

Phase: Not Applicable

Status: Recruiting

Condition: Stroke

Trial contact: 9348 1658

More information: https://clinicaltrials.gov/study/NCT06148051

Eligibility summary (AI generated)

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Adults aged 18 years or older
People who are able to give written consent to participate (a large-print version is available for people with visual impairment, and an easy-to-read version is available for people who need extra support due to cognitive difficulties)
People who are able to travel to a testing site in person
People who are able to complete a set of required assessments, including a medical examination, a medical history questionnaire, a blood test to check genetic status, and a short neuropsychology assessment (approximately 20 minutes)
People who have a confirmed diagnosis of CADASIL through genetic testing (a specific gene change called a NOTCH3 pathogenic variant), OR
People with a suspected CADASIL diagnosis based on their medical history and brain MRI results, OR
People who are a close blood relative (such as a parent, sibling, or child) of someone who has tested positive for the NOTCH3 gene change, OR
People who are not related to any trial participant, have tested negative for the NOTCH3 gene change, and have no concerns about their memory or thinking (these participants serve as a comparison group)

Who may not be able to join:

People whose level of cognitive impairment means they are unable to give informed consent to participate

Important: Always verify eligibility with the trial site directly before applying.

Access in Australia: A treatment being studied in a clinical trial is generally not yet listed on the PBS. Where a medicine is not approved or not available through a trial, the TGA Special Access Scheme may allow a doctor to access unapproved therapeutic goods for individual patients. See voxsanity.com.au/sas-navigator/ for a plain English explainer.

This information was sourced from ClinicalTrials.gov via Voxsanity (data last synced 26 July 2026). It is not medical advice. Please verify the trial's current status directly with the trial site before acting.

Trial details

Status

Recruiting

Phase

Not Applicable

Sponsor

Perminder Sachdev

Registry

ClinicalTrials.gov

Start date

25 November 2023

Est. completion

31 March 2027

Where this trial is recruiting

🇦🇺 Australia

5 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Online Medical Questionnaire; Weight and height will be combined to report BMI in kg/m^2; Blood Pressure; Modified Rankin Scale (mRS); National Institute of Health Stroke Scale (NIHSS); Alphabet required for Trail Making A/B; Montreal Cognitive Assessment (MoCA); Category Fluency (animals); Digit Span Backwards (WAIS-IV); National Institute of Health Computerised Toolbox (NIHCTB); Letter Fluency (FAS); Rey Auditory Verbal Learning Test (RAVLT); Brain MRI scan (total scan time 60 mins)- includes T1 weighted imaging; Brain MRI scan (total scan time 60 mins)- includes T2-weighted fluid attenuated...

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov