Stroke Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have had symptoms of an acute ischemic stroke (a stroke caused by a blockage) and your initial stroke severity score was below 6 points
• Your symptoms got worse within 7 days of your stroke first starting
• You can be enrolled in the study more than 24 hours after your stroke began (based on the last time you were known to be well)
• Your symptoms worsened within 24 hours before being enrolled in the study
• Your stroke severity score was 6 points or higher just before being enrolled
• You have given your written agreement to take part in the study
• A scan (CTA or MRA) has confirmed a blockage in a specific major brain artery (the internal carotid artery or the main branch of the middle cerebral artery)
• Your worsening symptoms are linked to reduced blood flow in the same area of the brain affected by your stroke
• A brain scan score (called ASPECTS) shows your brain tissue is mostly still healthy (score of 6 or above)
• A special blood flow scan shows there is a salvageable area of brain at risk, with a small core of damage (less than 50ml), and a significant mismatch between damaged and at-risk tissue (confirm with trial site for full details)

Who may not be able to join:

• You had significant disability before your stroke (confirm with trial site)
• Scans show your symptoms are caused by bleeding in the brain, brain swelling, or another clear non-blockage cause
• There are physical features of your blood vessel that may make it too difficult or risky to perform the procedure (such as the vessel being too narrow, too twisty, or hard to reach)
• Multiple blood vessels are severely narrowed or blocked
• You have an untreated brain aneurysm, a brain tumour (except small, low-risk meningiomas), or an abnormal tangle of blood vessels in the brain
• You have had any bleeding in the brain in the past 6 months
• You have had bleeding in your stomach or urinary system, a heart attack, a head injury, or major surgery in the past month
• You have a known tendency to bleed — for example, very low platelet levels or you are taking blood thinners with levels outside a safe range
• You have severe heart, liver, or kidney problems, or another serious advanced illness
• You have a known allergy to iodine contrast dye or other treatment-related medicines, or a severe allergic reaction to contrast dye that cannot be controlled with medication
• Your blood pressure is very high and cannot be brought under control (consistently above 185/110 mmHg)
• Your blood sugar levels are dangerously low or very high (below 2.8 mmol/L or above 22.2 mmol/L)
• You are pregnant, or you are a woman of childbearing age with a positive pregnancy test
• Your expected survival is less than 1 year due to another serious condition such as cancer or severe heart or lung disease
• You are already taking part in another interventional clinical trial that could affect the results of this study
• You have a mental health, cognitive, or emotional condition that would make it difficult to understand or follow the study procedures, or the investigator has another reason they feel participation would not be appropriate or safe for you

Important: Always verify eligibility with the trial site directly before applying.