Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with one of the following: Hodgkin lymphoma, CD30-positive aggressive B-cell lymphoma, ALK-negative anaplastic T-cell lymphoma or other peripheral T-cell lymphoma, or ALK-positive anaplastic T-cell lymphoma
• People whose tumour has tested positive for a protein called CD30, confirmed by a certified pathology laboratory
• People aged 12 to 75 years old
• People whose liver is functioning within acceptable levels, based on a substance called bilirubin (a different, slightly higher limit applies to those with a condition called Gilbert syndrome — confirm with trial site)
• People whose liver enzyme levels (AST) are within an acceptable range
• People whose kidneys are functioning at an adequate level, based on a test called estimated GFR being above 70 mL/min
• People whose blood oxygen level is above 90% when breathing normal room air
• People with a general health and functioning score above 60% on standard medical scales (Karnofsky or Lansky)
• People who have recovered from the non-blood-related side effects of any previous chemotherapy
• People who are sexually active and are willing to use effective contraception during the trial and for 6 months after it ends; male partners are also required to use a condom
• People (or their legal guardian) who have read, understood, and signed the informed consent form

Who may not be able to join:

• People who have received an experimental cell therapy or vaccine within the past 6 weeks
• People who have received an experimental small molecule drug within the past 2 weeks
• People who have received a type of treatment targeting the CD30 protein (antibody-based) within the past 4 weeks
• People who have had an allergic reaction to products containing mouse-derived proteins
• People who are pregnant or breastfeeding
• People whose tumour is located in a place where any swelling could block their airway (assessed by the trial doctors)
• People currently taking steroid medications (such as prednisone) at a daily dose of 10 mg or more
• People with an active, serious bacterial, viral, or fungal infection that is not under control
• People with significant heart disease causing symptoms at rest or with minimal activity (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.