Prostate Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Men aged 18 years or older
• People who have been diagnosed with prostate cancer (a specific type called adenocarcinoma) confirmed by a tissue sample, where radical radiotherapy (a curative course of radiation treatment) is recommended
• People whose cancer has a Gleason score of 3+3, 3+4, or 4+3 (also called Grade Groups 1, 2, or 3 — these are low to intermediate risk categories)
• People whose cancer is classified as stage T2 or lower based on an MRI scan, meaning the cancer appears to be contained within the prostate
• People who have one or more tumours visible on a specialised type of MRI scan (called a multiparametric MRI or mpMRI) that meet certain quality thresholds, and where the biopsy results match what is seen on the scan
• People whose visible tumour takes up less than half of the prostate on any single scan image, and less than half of the total prostate volume
• People with a PSA blood test result below 20 ng/ml before starting any hormone therapy (if hormone therapy is being used)
• People who may or may not be receiving a short course of hormone therapy (less than 6 months), as decided by the treating doctor
• People with a general health status rated 0, 1, or 2 on the WHO Performance Scale (meaning able to carry out daily activities, possibly with some limitations)
• People who are willing and able to understand and sign a consent form
• People who are willing and able to complete regular questionnaires about their wellbeing throughout the study

Who may not be able to join:

• People who cannot have an MRI scan for medical reasons, such as having a pacemaker, certain metal implants in the body, or severe claustrophobia
• People with a urinary symptom score (IPSS) of 19 or higher, indicating significant urinary problems
• People whose high-grade cancer areas are not visible on MRI (confirm with trial site)
• People who have more than 100 millilitres of urine remaining in the bladder after urinating, if this has been measured
• People with a prostate gland larger than 90cc in volume
• People with other health conditions that could increase the risk of serious side effects from treatment, such as inflammatory bowel disease, or conditions that would prevent long-term follow-up
• People who have had a full hip replacement on one or both sides, or other metal implants in the pelvis that interfere with MRI scan quality
• People who have previously had radiotherapy to the pelvic area
• People whose cancer requires more than 6 months of hormone therapy, as assessed by the treating doctor
• People who have had another type of cancer in the past 2 years — exceptions may include certain skin cancers, a low-risk form of bladder cancer (where follow-up checks have come back clear), or small kidney masses being monitored without treatment

Important: Always verify eligibility with the trial site directly before applying.