Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with squamous cell carcinoma (a specific type of cancer) of the esophagus (food pipe), confirmed by a tissue biopsy.
• People whose cancer is locally advanced (has grown in the area around the esophagus) but has not spread through the bloodstream to other parts of the body.
• People whose cancer has been assessed as not suitable for surgery, either for medical reasons or because surgery is not the person's choice.
• People who were aged between 70 and 85 years old at the time of their cancer diagnosis.
• People who have not previously received any cancer treatment.
• People with an estimated life expectancy of more than 6 months.
• People who are reasonably functional in daily life — specifically, those with an ECOG performance score of 2 or lower, meaning they may have some symptoms but are able to care for themselves (confirm with trial site for exact definition).
• People with no history of any other cancer, past or current.
• People whose blood, liver, and kidney test results meet specific minimum levels required by the trial (confirm with trial site for exact values).
• People who are able to understand the study and agree to participate by signing a consent form.

Who may not be able to join:

• People who have already received any form of cancer treatment, including chemotherapy, radiotherapy, surgery, or immunotherapy.
• People whose cancer has already spread through the bloodstream to other parts of the body, or who have an esophageal fistula (an abnormal opening in the food pipe) at the time of diagnosis.
• People with a known or suspected allergy or sensitivity to monoclonal antibody medicines, to the study drug cadonilimab, or to the chemotherapy drugs paclitaxel or cisplatin.
• People who have a pre-existing or current bleeding disorder.
• People who are unable to give informed consent due to psychological, family, social, or other personal circumstances.
• People who have moderate or severe peripheral neuropathy (nerve damage causing numbness, tingling, or weakness, typically in the hands or feet) — specifically, grade 2 or higher (confirm with trial site).
• People with a history of any other cancer before enrolling in the trial, with the exception of certain non-serious skin cancers, cervical cancer that had not spread, or prostate cancer that was fully cured.
• People who have had diabetes for more than 10 years and whose blood sugar levels are poorly controlled.
• People who cannot tolerate chemotherapy and radiation treatment due to serious heart, lung, liver, or kidney problems, blood disorders, or severe malnutrition (cachexia).
• People with active autoimmune diseases (where the immune system attacks the body), a history of autoimmune conditions (such as colitis, hepatitis, or an overactive thyroid), a weakened immune system including HIV, or a history of organ or bone marrow transplant.
• People with a history of interstitial lung disease or non-infectious pneumonia (a type of lung inflammation not caused by infection).
• People who have had active tuberculosis (TB) in the lung within the past year, or who had active lung TB more than a year ago but did not complete proper TB treatment.
• People with currently active hepatitis B or hepatitis C infections at levels above the thresholds set by the trial (confirm with trial site for exact values).

Important: Always verify eligibility with the trial site directly before applying.