Phase 3 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years, male or female
• People whose cancer has been confirmed by laboratory testing (biopsy or cell sample) to be squamous cell carcinoma of the esophagus or the junction between the esophagus and stomach
• People whose esophageal squamous cell carcinoma has come back or spread, and who have already received treatment with a PD-1 or PD-L1 immunotherapy drug, plus at least two prior lines of treatment overall
• People who have at least one tumor that can be measured on scans, according to standard criteria (called RECIST 1.1)
• People with a good general health and activity level, rated 0 or 1 on a standard scale used by doctors (meaning fully active or able to carry out light work)
• People expected to live longer than 12 weeks
• People with a body mass index (BMI) of at least 16.0 and a body weight of at least 40 kg
• People whose blood test results show their bone marrow, kidneys, and liver are functioning well enough
• Women who could become pregnant must have a negative blood pregnancy test done within 7 days before joining the trial
• People who are willing to take part voluntarily and sign a consent form

Who may not be able to join:

• People with cancer that has spread to the brain or spinal cord (central nervous system) that has not been treated
• People who have had another type of cancer within the past 5 years
• People with certain abnormalities or problems affecting the digestive system (confirm with trial site for specifics)
• People with certain heart or blood vessel conditions (confirm with trial site for specifics)
• People who have previously received a type of drug that targets blood vessel growth (vascular targeting inhibitor)
• People who have previously been treated with any of these specific medicines: Irinotecan, Docetaxel, or Tegafur Gimeracil Oteracil Potassium
• People who have taken part in another clinical trial within the 4 weeks before joining; or who have had radiotherapy, immunotherapy, or surgery for cancer within the 4 weeks before joining; or who have taken certain targeted cancer drugs within 2 weeks or 5 half-lives (whichever is longer); or who have had chemotherapy within 3 weeks or 5 half-lives (whichever is longer)
• People who still have unresolved side effects from previous cancer treatment that have not returned to a mild or absent level
• People with large amounts of fluid build-up in the abdomen, around the lungs, or around the heart that cannot be controlled
• People who have had a serious infection within the 4 weeks before joining
• People with a known HIV infection, or currently active hepatitis B or C infection
• Women who are pregnant or breastfeeding
• Women who could become pregnant, or men who could father a child, who are not willing to use contraception during the trial and for 6 months after it ends
• People considered ineligible for any other reason, as assessed by the trial doctors

Important: Always verify eligibility with the trial site directly before applying.